Table 3 Pathology, cytokines and growth factors resulting when tracheal allografts are transplanted into the rat subcutaneous pouch
From: The heterotopic tracheal allograft as an animal model of obliterative bronchiolitis
| Â | Â | Harvest time | Luminal | Epithelial | Changes in | Â | Â |
|---|---|---|---|---|---|---|---|
Donor strain | Recipient strain | (days) | occlusion (%) | loss (%) | cytokines/GFs | n | Reference |
BN | Lewis | 14 | 26 | Â | Â | n.r. | [15] |
|  |  | 28 | 85 |  | IL-2R ↑ |  |  |
BN | Lewis | 9 | Â | 50 | Â | 8 | [16] |
| Â | Â | 14 | Partial | 100 | Â | 8 | Â |
| Â | Â | 21 | 100 | 100 | Â | 8 | Â |
| Â | Â | 28 | 100 | 100 | Â | 8 | Â |
| Â | Â | 56 | 100 | 100 | Â | 8 | Â |
BN | Lewis | 21 | 100 | 100 | Â | 5 | [46] |
BN | Lewis | 3 | Â | Mild | At all time points: | 5 | [43] |
|  |  | 7 |  |  | IL-2 ↑, IFN-γ↑, | 5 |  |
|  |  |  |  |  | RANTES ↑, MCP-1 ↑ |  |  |
| Â | Â | 21 | 100 | 100 | Â | 5 | Â |
BN | Lewis | 21 | 83 | Â | Â | n.r. | [73] |
BN | Lewis | 21 | 83 | 100 | Â | 5 | [48] |
BN | Lewis | 7 | 30 | 19 | RANTES ↑ | 5 | [49] |
|  |  | 21 | 90 | 100 | RANTES ↑ | 5 |  |