The heterotopic tracheal allograft as an animal model of obliterative bronchiolitis

Respiratory Research

Table 1 Pathology, cytokines and growth factors resulting when tracheal allografts are transplanted into the rat omentum

		Harvest time	Luminal	Epithelial	Changes in
Donor strain	Recipient strain	(days)	occlusion (%)	loss (%)	cytokines/GFs	n	Reference
Lewis	Lewis	2		72		7	[14]
		7		34		6
		14		17		6
Lewis	BN	14		94		6	[17]
BN	Lewis	7				n.r.	[15]
		14	31
		28	97		IL-2R ↑
BN	Lewis	14	31	100		5	[18]
		28	97	100		3
BN	Lewis	14	31	100		n.r.	[19]
		28	96	100
BN	Lewis	14	31	100		5	[20]
		28	98	100		5
DA (AG-B4, RT1^a)	WF (AG-B2, RT1^u)	10	Marked occlusion			6	[26]
		30	100	100		6
BN (RT1ⁿ)	Lewis (RT1^l)	1		14		5	[22]
		3		69		5
		7	12	84		5
		14	30	100		5
		21	37	100		5
		28	99	100		5
BN (RT1ⁿ)	Lewis (RT1^l)	7	15			7	[24]
		14	29			7
		21	41	100		7
DA (AG-B4, RT1^a)	WF (AG-B2, RT1^u)	3	3	90		12	[27]
		10	10	98	At 10 days, IL-1α↑	10
					IL-1β↑, IFN-γ↑
					IL-2 ↑, iNOS ↑
		30	79	100		14
ACI (RT1A^a)	WF (RT1A^u)	30	100	100		10	[29]
Lewis (RT1A^l)	PVG (RT1^u)	14	Occurred but not graded	100		3	[69]
		28		100		3
BN (RT1Aⁿ)	Lewis (RT1A^l)	28	100			n.r.	[32]
BN (RT1ⁿ)	Lewis (RT1^l)	28	100			3	[31]
DA (AG-B4, RT1^a)	WF (AG-B2, RT1^u)	3			PDGF-AA ↑	10	[28]
		10	17	80	PDGF-AA↑	10
		30	85	100		10
BN (RT1ⁿ)	Lewis (RT1^l)	3		Damaged	iNOS ↑	6	[60]
		10		100	iNOS ↑	4
		60	100		iNOS ↑	2
BN (RT-1)	Lewis (RT-1)	28	100	100		5-10	[35]
		50	100	100
Lewis	BN	28		~100		6	[36]
BN	Lewis	28	>75	>75		5	[37]
		42	>75	>75		5

GFs, growth factors; IFN-γ, interferon-γ ; IL, interleukin; IL-2R, IL-2 receptor; iNOS, inducible nitric oxide synthase; n.r., not reported; PDGF, platelet-derived growth factor.

ISSN: 1465-993X