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Table 1 Genes associated with IL-4 and IL-4 signaling linked to asthma and allergies

From: Th2 cytokines and asthma — Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists

Gene Polymorphism Location Reference
Interleukin-4 promoter A→G -81 [32]
  C→T -285 [32]
  C→T -590 [33]
Interleukin-4 receptor, α chain Ile→Val +50 [34]
  Arg→Gln +551 [35]
  Ser→Pro +503 [36]
Interleukin-13 receptor, α chain A→G +1398 [37]
Stat-6 G→A +2964 (3' UTR) [38]
BCL6 HindIII 5' untranslated region [39]