Th2 cytokines and asthma — Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists

Table 1 Genes associated with IL-4 and IL-4 signaling linked to asthma and allergies

Gene	Polymorphism	Location	Reference
Interleukin-4 promoter	A→G	-81	[32]
	C→T	-285	[32]
	C→T	-590	[33]
Interleukin-4 receptor, α chain	Ile→Val	+50	[34]
	Arg→Gln	+551	[35]
	Ser→Pro	+503	[36]
Interleukin-13 receptor, α chain	A→G	+1398	[37]
Stat-6	G→A	+2964 (3' UTR)	[38]
BCL6	HindIII	5' untranslated region	[39]

ISSN: 1465-993X