Figure 4
Progression model for glandular neoplasia of the lung. The clinical (row 1) and histologic (row 2) progression of glandular neoplasia is driven at the genetic level (row 3) by the accumulation of specific alterations of oncogenes and tumor suppressor genes. These genetic alterations tend to follow a consistent, but not invariable, chronological order. LOH, loss of heterozygosity.