Table 1 Hypoxia-inducible gene expression
From: Oxygen-regulated transcription factors and their role in pulmonary disease
Gene product | Transcription factor* |
|---|---|
Adenylate kinase 3 | HIF-1 |
α1B-Adrenergic receptor | HIF-1 |
Adrenomedullin | HIF-1 |
Aldolase A | HIF-1 |
Aldolase C | HIF-1 |
Carbonic anhydrase-9 | HIF-1 |
Ceruloplasmin | HIF-1 |
Cyclooxygenase-2 | HMG I(Y), NF-κB |
Endothelin-1 | HIF-1 |
Enolase-1 | HIF-1 |
Erythropoietin | HIF-1 |
GADD153 | Not determined |
Glucose transporter-1 | HIF-1 |
Glucose transporter-3 | HIF-1 |
Glyceraldehyde-3-phosphate | HIF-1 |
dehydrogenase | Â |
Heme oxygenase-1 | AP-1, HIF-1 |
Hexokinase-1 | HIF-1 |
Hexokinase-2 | HIF-1 |
Insulin-like growth factor-2 (IGF-2) | HIF-1 |
IGF-binding protein-1 | HIF-1 |
IGF-binding protein-2 | HIF-1 |
IGF-binding protein-3 | HIF-1 |
Interleukin-6 | NF-IL6 |
Lactate dehydrogenase A | HIF-1 |
Nitric oxide synthase-2 | HIF-1 |
NIP3 | HIF-1 |
Ornithine decarboxylase | Not determined |
p21 | HIF-1 |
p27 | Not determined |
p35srj | HIF-1 |
Phosphofructokinase L | HIF-1 |
Phosphoglycerate kinase-1 | HIF-1 |
Plasminogen activator inhibitor-1 | HIF-1 |
Prolyl-4-hydroxylase α (I) | HIF-1 |
Pyruvate kinase M | HIF-1 |
Tissue factor | EGR-1 |
Transferrin | HIF-1 |
Transferrin receptor | HIF-1 |
Transforming growth factor β3 | HIF-1 |
Triosephosphate isomerase | HIF-1 |
Tyrosine hydroxylase | AP-1 |
Vascular endothelial growth factor (VEGF) | HIF-1 |
VEGF receptor FLT-1 | HIF-1 |