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Table 2 Effect of dexamethasone treatment on inflammatory cell numbers in bronchoalveolar lavage (BAL) fluid and lung tissue after the last antigen challenge in sensitised mice

From: Dissociation by steroids of eosinophilic inflammation from airway hyperresponsiveness in murine airways

Cell type

Vehicle saline

Vehicle OA

Dex 0.01 OA

Dex 0.03 OA

Dex 0.1 OA

Dex 0.3 OA

Dex 1 OA

Dex 3 OA

BAL eosinophils

0.6 ± 0.2

180.3 ± 34.6*

239.8 ± 76.5

129.9 ± 45.3

66.9 ± 20.6

43.6 ± 11.5*

4.6 ± 1.7*

3.6 ± 2.1*

BAL neutrophils

0.7 ± 0.3

449.4 ± 76.7*

617.9± 196.7

335.2 ± 93.9

218.8 ± 59.5

173.6 ± 46.8

38.5 ± 11.2*

29.8 ± 10.2*

BAL macrophages

104.4 ± 16.5

68.6 ± 12.7

79.9 ± 14.2

91.5 ± 14.2

57.0 ± 11.3

65.5 ± 5.5

71.7 ± 10.5

70.9 ± 4.7

BAL monocytes

10.2 ± 2.0

62.4 ± 8.5*

68.6 ± 19.5

52.2 ± 14.0

37.7 ± 9.2

25.8 ± 6.5

6.1 ± 1.0*

6.6 ± 1.6*

BAL Lymphocytes

6.2 ± 1.8

80.4 ± 12.9*

111.5 ± 39.1

62.3 ± 18.0

37.4 ± 13.0

28.2 ± 6.7

5.6 ± 1.2*

6.9 ± 1.7*

Tissue eosinophils

823 ± 108

4944 ± 715*

5480 ± 1323

4033 ± 734

3479 ± 713

2703 ± 328*

2557 ± 519*

2739 ± 476*

Tissue neutrophils

4948 ± 622

21869 ± 2756*

22884 ± 4686

22261 ± 5450

16166 ± 2473

14520 ± 1767

15188 ± 1750

18619 ± 1805

Tissue macrophages

571 ± 95

4721 ± 1277*

4590 ± 1266

3602 ± 754

2887 ± 841

2267 ± 714

689 ± 239*

311 ± 125*

Tissue monocytes

367 ± 78

6889 ± 1316*

7946 ± 2196

5524 ± 1524

3923 ± 993

2737 ± 1168

304 ± 69*

196 ± 75*

Tissue lymphocytes

1069 ± 98

8277 ± 1327*

8292 ± 2638

5912 ± 1696

3990 ± 959

3440 ± 959

707 ± 156*

691 ± 116.5*

  1. The concentration of cells in BAL fluid was 103/ml (the volume of BAL recovered in the lavage in this experiment was 0.6 ml from each animal) and that of tissue cells was 103/mg of tissue. Results are means ± SEM (n = 10). Asterisks indicate a significant difference (P < 0.05) from the relevant vehicle-dosed control group. OA, Ovalbumin.
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Respiratory Research

ISSN: 1465-993X

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