Dissociation by steroids of eosinophilic inflammation from airway hyperresponsiveness in murine airways

Respiratory Research

Table 1 Effect of dexamethasone treatment on inflammatory cell numbers in bronchoalveolar lavage (BAL) fluid and lung tissue after the last antigen challenge in sensitised mice

Parameter	Eosinophils	Neutrophils	Macrophages	Monocytes	Lymphocytes	MCh challenge (3 mg/ml)
BAL ED₅₀	0.08	0.14	-	0.09	0.10	-
Tissue ED₅₀	0.06	-	0.13	0.13	0.08	-
AHR peak changes, ED₅₀	-	-	-	-	-	0.35
AHR AUC changes, ED₅₀	-	-	-	-	-	0.32

Results are expressed as ED₅₀ values, in mg/kg of dexamethasone. AHR, airway hyperresponsiveness; AUC, area under the curve; MCh, methacholine.

ISSN: 1465-993X