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Table 1 Proteins encoded by genes directly targeted by HIF-1α

From: Oxygen-sensing mechanisms and the regulation of redox-responsive transcription factors in development and pathophysiology

Role

Protein

Glucose/energy metabolism Cell proliferation/viability

Adenylate kinase 3

 

Aldolase a

 

Aldolase c

 

Enolase-1

 

Glucose transporter 1

 

Glucose transporter 3

 

Glyceraldehyde-3-phosphate dehydrogenase

 

Hexokinase 1

 

Hexokinase 2

 

Insulin-like growth factor (IGF)-2

 

IGF-binding protein (IGFBP)-1

 

IGFBP-3

 

Lactate dehydrogenase a

 

Phosphoglycerate kinase 1

 

Pyruvate kinase m

 

p21

 

Transforming growth factor

Erythropoiesis Iron metabolism

Ceruloplasmin

 

Erythropoietin

 

Transferring

 

Transferrin receptor

Vascular development/remodelling Vasomotor tone

Adrenergic receptor

 

Adrenomedullin

 

Endothelin-1

 

Heme oxygenase-1

 

Nitric oxide synthase 2

 

Plasminogen activator inhibitor 1

 

Vascular endothelial growth factor (VEGF)

 

VEGF receptor FLT-1