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Figure 6 | Respiratory Research

Figure 6

From: Oxygen-sensing mechanisms and the regulation of redox-responsive transcription factors in development and pathophysiology

Figure 6

Rel/NF-κB signal transduction. Various extracellular signals converge on the activated IκB kinase complex. IκB kinase phosphorylates IκB at two N-terminal serines; phosphorylation signals IκB for ubiquitination and proteolysis in the proteasome. The NF-κB (p50-RelA in this case) released in this way enters the nucleus and activates gene expression. One NF-κB target gene (ikba) encodes IκB. The newly synthesized IκB can enter the nucleus, pull NF-κB off DNA, and export NF-κB back to its resting state in the cytoplasm. Thick lines indicate the activating pathway; thin lines indicate the inactivating pathway.

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