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Table 4 Potential alterations in human disease

From: Surfactant protein-D and pulmonary host defense

Disease Abnormality References
Cystic fibrosis Decreased accumulation or [111]
  depletion  
Acute interstitial Decreased accumulation or [112]
pneumonias (ARDS) depletion  
Cigarette smoking Decreased levels in lavage [113]
Bronchopulmonary Decreased accumulation or [114,115]
dysplasia depletion  
Asthma Altered activity [75]
Alveolar proteinosis. Increased accumulation [116,117]
Diabetes mellitus Decreased activity? [84]