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Table 3 Potential modulation of SP-D function

From: Surfactant protein-D and pulmonary host defense

Altered patterns of oligomerization
   Liberation of trimeric subunits secondary to proteolytic degradation
   Self-aggregation
Modifications of the CRD
   Proteolytic degradation
   Oxidative modification
   Local pH and calcium concentration
Competing ligands
   LPS
   Microorganisms
Host lectins with overlapping specificity
   Mannose receptor
   Other collectins (SP-A, mannose-binding lectin)
   Non C-type lectins (such as ficolins)