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Table 3 Potential modulation of SP-D function

From: Surfactant protein-D and pulmonary host defense

Altered patterns of oligomerization
   Liberation of trimeric subunits secondary to proteolytic degradation
Modifications of the CRD
   Proteolytic degradation
   Oxidative modification
   Local pH and calcium concentration
Competing ligands
Host lectins with overlapping specificity
   Mannose receptor
   Other collectins (SP-A, mannose-binding lectin)
   Non C-type lectins (such as ficolins)