Clinical perspectives on the association between respiratory syncytial virus and reactive airway disease

Table 1 Studies investigating the link between respiratory syncytial virus bronchiolitis and reactive airway disease

Reference	Year	Number of children (index/control)	Hospitalized	Age at follow up (years)	Presence of wheezing/asthma (index versus control)	P (odds ratio)	Abnormal PFTs in index cases
[5]	1978	35/35	Yes	8	51% versus 3%^*	<0.0005	Yes
[6]	1982	130/111	Yes	10	42% versus 19%^*	<0.001	Yes
[8]	1984	100/200	Yes	7	N/A	N/A	Yes
[15]	1984	59/177	No	8	44% versus 14%^†	<0.0001	-
[9]	1987	51/24	Yes	2	60% versus 4%^†	<0.01	-
[10]	1992	73/73	Yes	6	43% versus 15%^†	<0.001	Yes
[12]	1993	70/70	Yes	2	44% versus 13%^†	= 0.001	-
[4]	1995	47/93	Yes	3	23% versus 1%^†	<0.001	-
[11]	1997	61/47	Yes	9–10	34% versus 13%^†	(3.59)	Yes
[17]	1999	N/A	No	6	N/A	(4.3)	-
		N/A	No	13	N/A	(1.4; NS)	-
[13]	1999	105/105 and 102	Yes	3	N/A	NS at age 3 years	-
[14]	2000	47/93	Yes	7.5	23% versus 2%^†	<0.001	-

All numbers were rounded to one significant figure. ^*Cumulative rates of wheezing/asthma. ^†Rates in the current year. N/A, no percentages or figures given; NS, not significant; PFT, pulmonary function test.