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Table 1 Studies investigating the link between respiratory syncytial virus bronchiolitis and reactive airway disease

From: Clinical perspectives on the association between respiratory syncytial virus and reactive airway disease

Reference Year Number of children (index/control) Hospitalized Age at follow up (years) Presence of wheezing/asthma (index versus control) P (odds ratio) Abnormal PFTs in index cases
[5] 1978 35/35 Yes 8 51% versus 3%* <0.0005 Yes
[6] 1982 130/111 Yes 10 42% versus 19%* <0.001 Yes
[8] 1984 100/200 Yes 7 N/A N/A Yes
[15] 1984 59/177 No 8 44% versus 14% <0.0001 -
[9] 1987 51/24 Yes 2 60% versus 4% <0.01 -
[10] 1992 73/73 Yes 6 43% versus 15% <0.001 Yes
[12] 1993 70/70 Yes 2 44% versus 13% = 0.001 -
[4] 1995 47/93 Yes 3 23% versus 1% <0.001 -
[11] 1997 61/47 Yes 9–10 34% versus 13% (3.59) Yes
[17] 1999 N/A No 6 N/A (4.3) -
   N/A No 13 N/A (1.4; NS) -
[13] 1999 105/105 and 102 Yes 3 N/A NS at age 3 years -
[14] 2000 47/93 Yes 7.5 23% versus 2% <0.001 -
  1. All numbers were rounded to one significant figure. *Cumulative rates of wheezing/asthma. Rates in the current year. N/A, no percentages or figures given; NS, not significant; PFT, pulmonary function test.