Figure 2
From: Potential therapeutic implications of new insights into respiratory syncytial virus disease
Production of lung eosinophilia in the mouse model of respiratory syncytial virus (RSV). Lung eosinophilia is linked to the inability of the major surface glycoprotein G of RSV (RSV G-protein) to stimulate T-helper (Th)1, or CD8+, cells to produce IFN-γ. Once activated, Th1 cells stimulate macrophages and dendritic cells to produce IL-12. This induces natural killer (NK) cells and Th1 cells to produce IFN-γ. In the presence of IFN-γ lung eosinophilia is inhibited; in its absence the Th2 response persists. Th2 cells produce IL-4 and IL-5, which causes lung eosinophilia. Adapted with permission from Openshaw et al. [25]. rVV, recombinant vaccinia virus.