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Table 1 SLPI and elafin characteristics

From: The role of secretory leukocyte proteinase inhibitor and elafin (elastase-specific inhibitor/skin-derived antileukoprotease) as alarm antiproteinases in inflammatory lung disease

Property SLPI ESI/elafin/SKALP
Family name Four disulfide core Four disulfide core/trappin
Molecular mass (kDa) 11.7 9.8
Spectrum of protease inhibition HNE, trypsin, chymotrypsin, tryptase, HNE, pig pancreatic elastase, proteinase-3
  chymase, cathepsin G  
Cell and tissue distribution in lung Tracheal, bronchial, Clara, alveolar type II cells, Tracheal, Clara, alveolar type II cells,
  monocytes, alveolar macrophages, neutrophils alveolar macrophages
Regulatory stimuli LPS, IL-1, TNF, HNE IL-1, TNF, HNE
Biological properties Antimicrobial, antiviral, anti-HNE, inhibition of Antimicrobial, anti-HNE
  monocyte inflammatory potential  
Gene therapy potential Currently being explored Adenovirus-elafin protects against lung injury
   (rodent model)
  1. HNE = neutrophil elastase.