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Table 2 Criteria for designing high-quality association studies and interpreting the results

From: Genetic polymorphisms in lung disease: bandwagon or breakthrough?

Accurate narrow definition of the phenotype
A priori estimate of study power
Large sample size
Well-matched controls
P values adjusted for the number of polymorphisms tested
Biological plausibility and functional significance of candidate genes
Independent replication in other populations
Confirmation in family-based studies (transmission disequilibrium test, haplotype relative risk)