Table 2 Criteria for designing high-quality association studies and interpreting the results
From: Genetic polymorphisms in lung disease: bandwagon or breakthrough?
Accurate narrow definition of the phenotype |
A priori estimate of study power |
Large sample size |
Well-matched controls |
P values adjusted for the number of polymorphisms tested |
Biological plausibility and functional significance of candidate genes |
Independent replication in other populations |
Confirmation in family-based studies (transmission disequilibrium test, haplotype relative risk) |