Skip to main content

Table 2 Criteria for designing high-quality association studies and interpreting the results

From: Genetic polymorphisms in lung disease: bandwagon or breakthrough?

Accurate narrow definition of the phenotype

A priori estimate of study power

Large sample size

Well-matched controls

P values adjusted for the number of polymorphisms tested

Biological plausibility and functional significance of candidate genes

Independent replication in other populations

Confirmation in family-based studies (transmission disequilibrium test, haplotype relative risk)