Table 5 Airway smooth muscle (ASM) cell-derived arachidonic acid metabolites, their target cells and effects
From: Autocrine regulation of asthmatic airway inflammation: role of airway smooth muscle
Cyclooxygenase product | Target | Effect | Reference |
|---|---|---|---|
PGD | ASM | Contraction | |
|  | Goblet cell | Mucous secretion↑ |  |
PGE | ASM | Contraction, proliferation↓ GM-CSF secretion↓ | |
|  | Goblet cell | Mucous secretion↑ |  |
|  | Mast cell | Secretion↓ |  |
|  | Eosinophil | Recruitment and survival↓ |  |
|  | T cell | IL-2 secretion↓ |  |
PGF | ASM | Contraction | |
|  | Goblet cell | Mucous secretion↑ |  |
Thromboxane | ASM | Contraction and proliferation↑ |