Autocrine regulation of asthmatic airway inflammation: role of airway smooth muscle

Respiratory Research

Table 3 Airway smooth muscle cell-derived chemokines, their target cells and effects

Chemokine	Target	Effect	Ref
IL-8	Neutrophil	Recruitment, activation↑	[34]
	Eosinophil, T cell	Recruitment
Eotaxin	Eosinophil, T cells, basophil	Recruitment	[23,24,29,34,85,86]
	Mast cell	Induces growth
RANTES	Eosinophil, T cells, monocytes	Recruitment	[23,24,29,34]
GM-CSF	Eosinophil, mq, monocyte	Recruitment, activation↑, proliferation↑	[34]
	Neutrophil	Survival↑
MCP	Monocytes, lymphocytes, eosinophil, basophil,	Recruitment, activation↑	[23,24,29]
	dendritic cells, NK cells
	mθ	IL-1 secretion↑
MIP-1a	Eosinophil, NK, T cells, monocytes, mast cell, basophil	Recruitment, activation↑	[23,24]

↑, Increase; GM-CSF, granulocyte/macrophage-colony stimulating factor; IL, interleukin; MCP, monocyte chemotactic protein; MIP, macrophage inflammatory protein; mθ, macrophage; NK, natural killer; RANTES, regulated on activation, normal T cell expressed and secreted.

ISSN: 1465-993X