Glutathione-S-transferases in lung and sputum specimens, effects of smoking and COPD severity

Respiratory Research

Table 1 Patient characteristics of the specimens examined by immunohistochemistry

	Non-smoker N = 16	Smoker N = 22	COPD N = 34	p-value
Age, years	65 (13)	63 (8)	62 (9)	0.543
Sex M:F	8:8	17:5	27:7	0.103
Pack-years	0	46 (19)*	38 (13)§	0.000
FEV1 %predicted	98 (15)	90 (10)	55 (23)*#	0.000
FEV1/FVC %	86 (9)	83 (11)	56 (15)*#	0.000
MEF50 %pred	94 (24)	80 (37)	34 (21)*#	0.000
DCO %pred	91 (15)	78 (14)	64 (27)§	0.004
DCO/VA %pred	89 (11)	83 (12)	72 (24) §	0.035

Mean (SD)
*The mean difference between non-smokers and smokers is significant at the 0.05 level, Dunnett t-test.
§The mean difference between non-smokers and COPD-patients is significant at the 0.05 level, Dunnett t-test.
# The mean difference between smokers and COPD-patients is significant at the 0.05 level, Dunnett t-test.

ISSN: 1465-993X