Figure 6

Effects of P2 receptor antagonist on lung inflammation caused by large tidal volume mechanical ventilation. A. The pre-instillation, 60 min before the onset of mechanical ventilation, of PPADS (60 μl of 50 mM) attenuated the increase in W/D weight ratio caused by large tidal volume mechanical ventilation for 60 min, though the difference was not statistically significant. n = 16 mice in each group; *p < 0.05 vs. control. B. Pre-treatment with PPADS did not significantly inhibit the induction of MIP-2 mRNA following large tidal volume ventilation. n = 8 mice in each group; *p < 0.05 vs. control. C. Pre-treatment with PPADS inhibited the induction of IL-6 following large tidal volume ventilation. n = 8 mice in each group; *p < 0.05 vs. control; #p < 0.05 vs. saline.