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Figure 3 | Respiratory Research

Figure 3

From: Acute lung inflammation and ventilator-induced lung injury caused by ATP via the P2Y receptors: an experimental study

Figure 3

Induction of expression of inflammatory cytokines by instillation of ATP. A. Inflammatory cytokine expression in early phase. The instillation of ATP increased significantly the mRNA expression of MIP-2 and IL-6 in 60 min. PPADS limited the increase in the expression of these genes. n = 8 mice in each group; *p < 0.05 vs. control; #p < 0.05 vs. ATP. B. Inflammatory cytokine expression in 24 h. The instillation of ATP increased significantly the mRNA expression of MIP-2, IL-6 and TNF-α, but not of IL-1β. PPADS limited the increase in the expression of MIP-2 and IL-6 gene. n = 8 mice in each group; *p < 0.05 vs. control; #p < 0.01 vs. ATP.

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