Figure 1

Effect of ozone exposure on survival rates of SP-A (-/-) mice afterK. pneumoniaeinfection: comparison with WT mice. SP-A (-/-) male and female mice on the C57BL/6 background were used in this study. The experimental design is as described in Methods. Data are represented in percent. FA groups are shown with solid circles and ozone groups – with open circles. Data for WT mice of the same genetic background (shown with dotted lines) are from Mikerov et al. [39], and are shown here for comparison purposes. In this analysis, males and females were analyzed together to study the effect of ozone on survival after pneumonia regardless of sex. Differences were found to be significant if p < 0.05 (shown under the Figure). Significant differences by log-rank test (cumulative survival, for all 14 days): ^#FA group of SP-A (-/-) or WT mice vs. the corresponding ozone SP-A (^-/-) or WT group; FA or ozone groups of SP-A (-/-) mice vs. the corresponding groups of WT mice. Significant differences by Chi-square test (daily survival): as above for cumulative survival, but for daily analysis each asterisk (*) corresponds to significant differences for the respective day located above.