TY - JOUR AU - Mikerov, Anatoly N. AU - Haque, Rizwanul AU - Gan, Xiaozhuang AU - Guo, Xiaoxuan AU - Phelps, David S. AU - Floros, Joanna PY - 2008 DA - 2008/12/04 TI - Ablation of SP-A has a negative impact on the susceptibility of mice to Klebsiella pneumoniae infection after ozone exposure: sex differences JO - Respiratory Research SP - 77 VL - 9 IS - 1 AB - Surfactant protein A (SP-A) enhances phagocytosis of bacteria, including Klebsiella pneumoniae, by alveolar macrophages. Ozone, a major air pollutant, can cause oxidation of surfactant and may influence lung immune function. Immune function may also be affected by sex-specific mechanisms. We hypothesized that ablation of SP-A has a negative impact on the susceptibility of mice to Klebsiella pneumoniae infection after ozone exposure, and that sex differences in the effect of ozone do exist. SN - 1465-993X UR - https://doi.org/10.1186/1465-9921-9-77 DO - 10.1186/1465-9921-9-77 ID - Mikerov2008 ER -