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Table 3 Exacerbations classified by severity

From: One-year treatment with mometasone furoate in chronic obstructive pulmonary disease

  MF-DPI 800 μg QD PM MF-DPI 400 μg BID Placebo
Total number of exacerbations 154 159 207
   Hospitalizations, n (%) 12 (8) 12 (8) 20 (10)
   Use of both oral steroid and antibiotic, n (%) 50 (32) 55 (35) 75 (36)
   Use of oral steroid alone, n (%) 26 (17) 31 (20) 51 (25)
   Use of antibiotic alone, n (%) 66 (43) 61 (38) 61 (30)
Exacerbation rates*    
   More severe exacerbations 0.36 0.41§ 0.69
   All exacerbations 0.62§ 0.65§ 0.96
  1. BID = twice daily; MF-DPI = mometasone furoate administered via a dry powder inhaler; QD PM = once daily in the evening.
  2. *Ratio between total number of events and total duration of treatment across all subjects.
  3. Resulting in hospitalization, use of both oral steroids and antibiotics, or of oral steroids alone, as opposed to use of antibiotics alone.
  4. P = 0.002 vs placebo
  5. §P ≤ 0.022 vs placebo