One-year treatment with mometasone furoate in chronic obstructive pulmonary disease

Table 3 Exacerbations classified by severity

	MF-DPI 800 μg QD PM	MF-DPI 400 μg BID	Placebo
Total number of exacerbations	154	159	207
Hospitalizations, n (%)	12 (8)	12 (8)	20 (10)
Use of both oral steroid and antibiotic, n (%)	50 (32)	55 (35)	75 (36)
Use of oral steroid alone, n (%)	26 (17)	31 (20)	51 (25)
Use of antibiotic alone, n (%)	66 (43)	61 (38)	61 (30)
Exacerbation rates*
More severe exacerbations^†	0.36^‡	0.41^§	0.69
All exacerbations	0.62^§	0.65^§	0.96

BID = twice daily; MF-DPI = mometasone furoate administered via a dry powder inhaler; QD PM = once daily in the evening.
*Ratio between total number of events and total duration of treatment across all subjects.
^†Resulting in hospitalization, use of both oral steroids and antibiotics, or of oral steroids alone, as opposed to use of antibiotics alone.
^‡P = 0.002 vs placebo
^§P ≤ 0.022 vs placebo