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Figure 2 | Respiratory Research

Figure 2

From: An intranasal selective antisense oligonucleotide impairs lung cyclooxygenase-2 production and improves inflammation, but worsens airway function, in house dust mite sensitive mice

Figure 2

(a). Relative expression of COX-2 mRNA in lung tissue from different treatment groups assayed by real-time PCR. The mRNA expression ratio in the non-sensitized mice was established as 1.0. The level of COX-2 mRNA was significantly diminished in the lungs of sensitized mice treated with the selective antisense oligonucleotide (ASO) when compared with both untreated and control oligonucleotide-treated sensitized mice (n = 12). 2 (b). Levels of COX-2 protein in the lung tissue of non-sensitized mice (n = 3) and in untreated and COX-2 ASO-treated HDM-sensitized mice (n = 6). 2 (c) PGE2 content in the bronchoalveolar lavage (BAL) of non-sensitized (n = 1) and HDM-sensitized treated (n = 4) and untreated (n = 3) mice (* p < 0.05). MM, mismatched oligonucleotide.

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Respiratory Research

ISSN: 1465-993X

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