Table 1 Summary of Inhibitors Tested.
Inhibitor | Target | Final Concentration | Vehicle |
|---|---|---|---|
Poly(I) | SR binding | 10 μg/ml | PBS |
Cytochalasin D | filamentous actin | 15 μM | DMSO |
Nocodazole | microtubules | 25 μM | DMSO |
Staurosporine | protein kinases | 1 μM | DMSO |
Chelerythrine Cl | PKC | 25 μM | DMSO |
Gö 6976 | PKC | 10 μM | DMSO |
Wortmannin | PI-3K | 0.04 μM | DMSO |
LY294002 | PI-3K | 200 μM | DMSO |
Genistein | tyrosine kinases | 100 μM | DMSO |
Herbimycin A | tyrosine kinases | 80 μM | DMSO |
MEK inhibitor I | MEK | 200 μM | DMSO |
JNK inhibitor I | JNK | 4 μM | PBS |
JNK control | inactive analog of JNK inhibitor I | 4 μM | PBS |
U-73122 | phospholipase C | 10 μM | DMSO |
U-73343 | inactive analog of U-73122 | 10 μM | DMSO |