Dynamics of pro-inflammatory and anti-inflammatory cytokine release during acute inflammation in chronic obstructive pulmonary disease: an ex vivo study

Table 2 Numbers of Macrophages, Mast cells and Neutrophils in lung tissue from COPD patients and individuals with normal lung function

	Normal lung Function (4M/6F)	GOLD I/II (6M/4F)	p Value
Lung function (FEV ₁ /FVC)	0.79 ± 0.02	0.62 ± 0.03	0.05
FEV ₁ % predicted	99.2 ± 9.7	77.2 ± 8.5	0.05
Smoking status	4 current smokers	4 current smokers
	3 ex-smokers	5 ex-smokers
	2 non-smokers
Age	64.7. ± 7.9	71.2 ± 2.0	0.07
Macrophage (CD68) cell/mm ²	2.8 ± 0.6	5.4 ± 1.4	0.10
Mast Cell (Tryptase) cell/mm ²	20.6 ± 5.5	17.1 ± 3.9	0.23
Neutrophil (Neutrophil elastase) cell/mm ²	8.1 ± 0.7	11.5 ± 3.6	0.15

Patient data including lung function given as the ratio of air that can be forcibly exhaled in one second (FEV₁) to the forced vital capacity (FVC), FEV₁/FVC and FEV₁% predicted, smoking status, age and gender are listed as the mean ± SEM. Cell numbers are listed as the mean number of cells/mm², ± SEM and the p value obtained when comparing the each factor between the two groups is given, p < 0.05 was considered statistically significant.

ISSN: 1465-993X