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Figure 3 | Respiratory Research

Figure 3

From: Dynamics of pro-inflammatory and anti-inflammatory cytokine release during acute inflammation in chronic obstructive pulmonary disease: an ex vivo study

Figure 3

TNFα, the key cytokine in the inflammatory response. Data from figures 1A and 2A, B, and 2C were re-plotted to analyse the relationship between TNFα release at 6 hrs and IL-6 (3A), CXCL8 (3B) and IL-10 (3C) release at 24 hrs. Data was analysed using Spearman rank correlation, the values given are the Rho and p < 0.05. To confirm the role of TNFα in the cytokine cascade human lung tissue (n = 37) was pre-treated with neutralising TNFα antibody (nTNFαAb) (grey circles) or an isotype control (open circles) for 1 hr and then stimulated with 100 ng/ml LPS (filled circles). The supernatants were analysed for IL-6 (3D), CXCL8 (3E), and IL-10 (3F) using commercial ELISAs. For all values given are the mean ± SEM and are expressed as pg/mg of tissue * indicates a P value < 0.05.

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Respiratory Research

ISSN: 1465-993X

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