TY - JOUR AU - Peabody, J. W. AU - Schau, B. AU - Lopez-Vidriero, M. AU - Vestbo, J. AU - Wade, S. AU - Iqbal, A. PY - 2005 DA - 2005// TI - COPD: a prevalence estimation model JO - Respirology VL - 10 UR - https://doi.org/10.1111/j.1440-1843.2005.00755.x DO - 10.1111/j.1440-1843.2005.00755.x ID - Peabody2005 ER - TY - STD TI - Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease. American Thoracic SocietyAm J Respir Crit Care Med 1995,152(5 Pt 2):S77–121. ID - ref2 ER - TY - CHAP AU - Society, A. T. S. E. R. PY - 2006 DA - 2006// TI - Definition, Diagnosis and Staging of COPD BT - American Thoracic Society Website 2006 Aug 23 ID - Society2006 ER - TY - JOUR AU - Jeffery, P. K. PY - 2004 DA - 2004// TI - Remodeling and inflammation of bronchi in asthma and chronic obstructive pulmonary disease JO - Proc Am Thorac Soc VL - 1 UR - https://doi.org/10.1513/pats.200402-009MS DO - 10.1513/pats.200402-009MS ID - Jeffery2004 ER - TY - JOUR AU - Cosio, M. G. AU - Guerassimov, A. PY - 1999 DA - 1999// TI - Chronic obstructive pulmonary disease. Inflammation of small airways and lung parenchyma JO - Am J Respir Crit Care Med VL - 160 UR - https://doi.org/10.1164/ajrccm.160.supplement_1.7 DO - 10.1164/ajrccm.160.supplement_1.7 ID - Cosio1999 ER - TY - JOUR AU - Burge, S. AU - Wedzicha, J. A. PY - 2003 DA - 2003// TI - COPD exacerbations: definitions and classifications JO - Eur Respir J Suppl VL - 41 UR - https://doi.org/10.1183/09031936.03.00078002 DO - 10.1183/09031936.03.00078002 ID - Burge2003 ER - TY - JOUR AU - Connors, A. F. AU - Dawson, N. V. AU - Thomas, C. AU - Harrell, F. E. AU - Desbiens, N. AU - Fulkerson, W. J. AU - Kussin, P. AU - Bellamy, P. AU - Goldman, L. AU - Knaus, W. A. PY - 1996 DA - 1996// TI - Outcomes following acute exacerbation of severe chronic obstructive lung disease. The SUPPORT investigators (Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments) JO - Am J Respir Crit Care Med VL - 154 UR - https://doi.org/10.1164/ajrccm.154.4.8887592 DO - 10.1164/ajrccm.154.4.8887592 ID - Connors1996 ER - TY - JOUR AU - Donaldson, G. C. AU - Seemungal, T. A. AU - Patel, I. S. AU - Lloyd-Owen, S. J. AU - Wilkinson, T. M. AU - Wedzicha, J. A. PY - 2003 DA - 2003// TI - Longitudinal changes in the nature, severity and frequency of COPD exacerbations JO - Eur Respir J VL - 22 UR - https://doi.org/10.1183/09031936.03.00038303 DO - 10.1183/09031936.03.00038303 ID - Donaldson2003 ER - TY - JOUR AU - Patel, I. S. AU - Seemungal, T. A. AU - Wilks, M. AU - Lloyd-Owen, S. J. AU - Donaldson, G. C. AU - Wedzicha, J. A. PY - 2002 DA - 2002// TI - Relationship between bacterial colonisation and the frequency, character, and severity of COPD exacerbations JO - Thorax VL - 57 UR - https://doi.org/10.1136/thorax.57.9.759 DO - 10.1136/thorax.57.9.759 ID - Patel2002 ER - TY - JOUR AU - Seemungal, T. A. AU - Donaldson, G. C. AU - Paul, E. A. AU - Bestall, J. C. AU - Jeffries, D. J. AU - Wedzicha, J. A. PY - 1998 DA - 1998// TI - Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease JO - Am J Respir Crit Care Med VL - 157 UR - https://doi.org/10.1164/ajrccm.157.5.9709032 DO - 10.1164/ajrccm.157.5.9709032 ID - Seemungal1998 ER - TY - CHAP AU - Wedzicha, J. A. ED - Lenfan, C. PY - 2003 DA - 2003// TI - Acute Exacerbations of Chronic Obstructibe Pulmonary Disease BT - Lung Biology in Health and Disease Volume 183 ID - Wedzicha2003 ER - TY - JOUR AU - Zalacain, R. AU - Sobradillo, V. AU - Amilibia, J. AU - Barron, J. AU - Achotegui, V. AU - Pijoan, J. I. AU - Llorente, J. L. PY - 1999 DA - 1999// TI - Predisposing factors to bacterial colonization in chronic obstructive pulmonary disease JO - Eur Respir J VL - 13 UR - https://doi.org/10.1034/j.1399-3003.1999.13b21.x DO - 10.1034/j.1399-3003.1999.13b21.x ID - Zalacain1999 ER - TY - JOUR AU - Soler, N. AU - Ewig, S. AU - Torres, A. AU - Filella, X. AU - Gonzalez, J. AU - Zaubet, A. PY - 1999 DA - 1999// TI - Airway inflammation and bronchial microbial patterns in patients with stable chronic obstructive pulmonary disease JO - Eur Respir J VL - 14 UR - https://doi.org/10.1183/09031936.99.14510159 DO - 10.1183/09031936.99.14510159 ID - Soler1999 ER - TY - JOUR AU - Monso, E. AU - Rosell, A. AU - Bonet, G. AU - Manterola, J. AU - Cardona, P. J. AU - Ruiz, J. AU - Morera, J. PY - 1999 DA - 1999// TI - Risk factors for lower airway bacterial colonization in chronic bronchitis JO - Eur Respir J VL - 13 UR - https://doi.org/10.1034/j.1399-3003.1999.13b20.x DO - 10.1034/j.1399-3003.1999.13b20.x ID - Monso1999 ER - TY - JOUR AU - Stockley, R. A. AU - O'Brien, C. AU - Pye, A. AU - Hill, S. L. PY - 2000 DA - 2000// TI - Relationship of sputum color to nature and outpatient management of acute exacerbations of COPD JO - Chest VL - 117 UR - https://doi.org/10.1378/chest.117.6.1638 DO - 10.1378/chest.117.6.1638 ID - Stockley2000 ER - TY - JOUR AU - Sethi, S. AU - Muscarella, K. AU - Evans, N. AU - Klingman, K. L. AU - Grant, B. J. AU - Murphy, T. F. PY - 2000 DA - 2000// TI - Airway inflammation and etiology of acute exacerbations of chronic bronchitis JO - Chest VL - 118 UR - https://doi.org/10.1378/chest.118.6.1557 DO - 10.1378/chest.118.6.1557 ID - Sethi2000 ER - TY - JOUR AU - Bhowmik, A. AU - Seemungal, T. A. AU - Sapsford, R. J. AU - Wedzicha, J. A. PY - 2000 DA - 2000// TI - Relation of sputum inflammatory markers to symptoms and lung function changes in COPD exacerbations JO - Thorax VL - 55 UR - https://doi.org/10.1136/thorax.55.2.114 DO - 10.1136/thorax.55.2.114 ID - Bhowmik2000 ER - TY - JOUR AU - Gompertz, S. AU - Bayley, D. L. AU - Hill, S. L. AU - Stockley, R. A. PY - 2001 DA - 2001// TI - Relationship between airway inflammation and the frequency of exacerbations in patients with smoking related COPD JO - Thorax VL - 56 UR - https://doi.org/10.1136/thorax.56.1.36 DO - 10.1136/thorax.56.1.36 ID - Gompertz2001 ER - TY - JOUR AU - Hurlimann, D. AU - Forster, A. AU - Noll, G. AU - Enseleit, F. AU - Chenevard, R. AU - Distler, O. AU - Bechir, M. AU - Spieker, L. E. AU - Neidhart, M. AU - Michel, B. A. AU - Gay, R. E. AU - Luscher, T. F. AU - Gay, S. AU - Ruschitzka, F. PY - 2002 DA - 2002// TI - Anti-tumor necrosis factor-alpha treatment improves endothelial function in patients with rheumatoid arthritis JO - Circulation VL - 106 UR - https://doi.org/10.1161/01.CIR.0000037521.71373.44 DO - 10.1161/01.CIR.0000037521.71373.44 ID - Hurlimann2002 ER - TY - JOUR AU - Sandborn, W. J. PY - 2005 DA - 2005// TI - New concepts in anti-tumor necrosis factor therapy for inflammatory bowel disease JO - Rev Gastroenterol Disord VL - 5 ID - Sandborn2005 ER - TY - JOUR AU - Howarth, P. H. AU - Babu, K. S. AU - Arshad, H. S. AU - Lau, L. AU - Buckley, M. AU - McConnell, W. AU - Beckett, P. AU - Al Ali, M. AU - Chauhan, A. AU - Wilson, S. J. AU - Reynolds, A. AU - Davies, D. E. AU - Holgate, S. T. PY - 2005 DA - 2005// TI - Tumour necrosis factor (TNFalpha) as a novel therapeutic target in symptomatic corticosteroid dependent asthma JO - Thorax VL - 60 UR - https://doi.org/10.1136/thx.2005.045260 DO - 10.1136/thx.2005.045260 ID - Howarth2005 ER - TY - JOUR AU - Pauwels, R. A. AU - Buist, A. S. AU - Calverley, P. M. AU - Jenkins, C. R. AU - Hurd, S. S. PY - 2001 DA - 2001// TI - Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary JO - Am J Respir Crit Care Med VL - 163 UR - https://doi.org/10.1164/ajrccm.163.5.2101039 DO - 10.1164/ajrccm.163.5.2101039 ID - Pauwels2001 ER - TY - BOOK PY - 2006 DA - 2006// TI - Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease ID - ref23 ER - TY - JOUR AU - Schulman, E. S. AU - Newball, H. H. AU - Demers, L. M. AU - Fitzpatrick, F. A. AU - Adkinson, N. F. PY - 1981 DA - 1981// TI - Anaphylactic release of thromboxane A2, prostaglandin D2, and prostacyclin from human lung parenchyma JO - Am Rev Respir Dis VL - 124 ID - Schulman1981 ER - TY - JOUR AU - Britten, K. M. AU - Howarth, P. H. AU - Roche, W. R. PY - 1993 DA - 1993// TI - Immunohistochemistry on resin sections: a comparison of resin embedding techniques for small mucosal biopsies JO - Biotech Histochem VL - 68 UR - https://doi.org/10.3109/10520299309105629 DO - 10.3109/10520299309105629 ID - Britten1993 ER - TY - JOUR AU - Bradding, P. AU - Okayama, Y. AU - Howarth, P. H. AU - Church, M. K. AU - Holgate, S. T. PY - 1995 DA - 1995// TI - Heterogeneity of human mast cells based on cytokine content JO - J Immunol VL - 155 ID - Bradding1995 ER - TY - JOUR AU - Armstrong, L. AU - Jordan, N. AU - Millar, A. PY - 1996 DA - 1996// TI - Interleukin 10 (IL-10) regulation of tumour necrosis factor alpha (TNF-alpha) from human alveolar macrophages and peripheral blood monocytes JO - Thorax VL - 51 UR - https://doi.org/10.1136/thx.51.2.143 DO - 10.1136/thx.51.2.143 ID - Armstrong1996 ER - TY - JOUR AU - Gazzinelli, R. T. AU - Wysocka, M. AU - Hieny, S. AU - Scharton-Kersten, T. AU - Cheever, A. AU - Kuhn, R. AU - Muller, W. AU - Trinchieri, G. AU - Sher, A. PY - 1996 DA - 1996// TI - In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha JO - J Immunol VL - 157 ID - Gazzinelli1996 ER - TY - JOUR AU - May, J. R. PY - 1953 DA - 1953// TI - The bacteriology of chronic bronchitis JO - Lancet VL - 265 ID - May1953 ER - TY - JOUR AU - Aaron, S. D. AU - Angel, J. B. AU - Lunau, M. AU - Wright, K. AU - Fex, C. AU - Le Saux, N. AU - Dales, R. E. PY - 2001 DA - 2001// TI - Granulocyte inflammatory markers and airway infection during acute exacerbation of chronic obstructive pulmonary disease JO - Am J Respir Crit Care Med VL - 163 UR - https://doi.org/10.1164/ajrccm.163.2.2003122 DO - 10.1164/ajrccm.163.2.2003122 ID - Aaron2001 ER - TY - JOUR AU - Hill, A. T. AU - Campbell, E. J. AU - Hill, S. L. AU - Bayley, D. L. AU - Stockley, R. A. PY - 2000 DA - 2000// TI - Association between airway bacterial load and markers of airway inflammation in patients with stable chronic bronchitis JO - Am J Med VL - 109 UR - https://doi.org/10.1016/S0002-9343(00)00507-6 DO - 10.1016/S0002-9343(00)00507-6 ID - Hill2000 ER - TY - JOUR AU - Armstrong, L. AU - Medford, A. R. AU - Uppington, K. M. AU - Robertson, J. AU - Witherden, I. R. AU - Tetley, T. D. AU - Millar, A. B. PY - 2004 DA - 2004// TI - Expression of functional toll-like receptor-2 and -4 on alveolar epithelial cells JO - Am J Respir Cell Mol Biol VL - 31 UR - https://doi.org/10.1165/rcmb.2004-0078OC DO - 10.1165/rcmb.2004-0078OC ID - Armstrong2004 ER - TY - JOUR AU - Supajatura, V. AU - Ushio, H. AU - Nakao, A. AU - Akira, S. AU - Okumura, K. AU - Ra, C. AU - Ogawa, H. PY - 2002 DA - 2002// TI - Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity JO - J Clin Invest VL - 109 UR - https://doi.org/10.1172/JCI0214704 DO - 10.1172/JCI0214704 ID - Supajatura2002 ER - TY - JOUR AU - Brewington, R. AU - Chatterji, M. AU - Zoubine, M. AU - Miranda, R. N. AU - Norimatsu, M. AU - Shnyra, A. PY - 2001 DA - 2001// TI - IFN-gamma-independent autocrine cytokine regulatory mechanism in reprogramming of macrophage responses to bacterial lipopolysaccharide JO - J Immunol VL - 167 UR - https://doi.org/10.4049/jimmunol.167.1.392 DO - 10.4049/jimmunol.167.1.392 ID - Brewington2001 ER - TY - JOUR AU - Chanteux, H. AU - Guisset, A. C. AU - Pilette, C. AU - Sibille, Y. PY - 2007 DA - 2007// TI - LPS induces IL-10 production by human alveolar macrophages via MAPKinases- and Sp1-dependent mechanisms JO - Respir Res VL - 8 UR - https://doi.org/10.1186/1465-9921-8-71 DO - 10.1186/1465-9921-8-71 ID - Chanteux2007 ER - TY - JOUR AU - Monick, M. M. AU - Yarovinsky, T. O. AU - Powers, L. S. AU - Butler, N. S. AU - Carter, A. B. AU - Gudmundsson, G. AU - Hunninghake, G. W. PY - 2003 DA - 2003// TI - Respiratory syncytial virus up-regulates TLR4 and sensitizes airway epithelial cells to endotoxin JO - J Biol Chem VL - 278 UR - https://doi.org/10.1074/jbc.M308093200 DO - 10.1074/jbc.M308093200 ID - Monick2003 ER - TY - JOUR AU - Birrell, M. A. AU - Wong, S. AU - Dekkak, A. AU - De Alba, J. AU - Haj-Yahia, S. AU - Belvisi, M. G. PY - 2006 DA - 2006// TI - Role of matrix metalloproteinases in the inflammatory response in human airway cell-based assays and in rodent models of airway disease JO - J Pharmacol Exp Ther VL - 318 UR - https://doi.org/10.1124/jpet.106.105544 DO - 10.1124/jpet.106.105544 ID - Birrell2006 ER - TY - JOUR AU - Tumkaya, M. AU - Atis, S. AU - Ozge, C. AU - Delialioglu, N. AU - Polat, G. AU - Kanik, A. PY - 2007 DA - 2007// TI - Relationship between airway colonization, inflammation and exacerbation frequency in COPD JO - Respir Med VL - 101 UR - https://doi.org/10.1016/j.rmed.2006.08.020 DO - 10.1016/j.rmed.2006.08.020 ID - Tumkaya2007 ER - TY - JOUR AU - Hacievliyagil, S. S. AU - Gunen, H. AU - Mutlu, L. C. AU - Karabulut, A. B. AU - Temel, I. PY - 2006 DA - 2006// TI - Association between cytokines in induced sputum and severity of chronic obstructive pulmonary disease JO - Respir Med VL - 100 UR - https://doi.org/10.1016/j.rmed.2005.08.022 DO - 10.1016/j.rmed.2005.08.022 ID - Hacievliyagil2006 ER - TY - JOUR AU - Donaldson, G. C. AU - Seemungal, T. A. AU - Bhowmik, A. AU - Wedzicha, J. A. PY - 2002 DA - 2002// TI - Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease JO - Thorax VL - 57 UR - https://doi.org/10.1136/thorax.57.10.847 DO - 10.1136/thorax.57.10.847 ID - Donaldson2002 ER - TY - JOUR AU - Hurst, J. R. AU - Perera, W. R. AU - Wilkinson, T. M. AU - Donaldson, G. C. AU - Wedzicha, J. A. PY - 2006 DA - 2006// TI - Exacerbation of chronic obstructive pulmonary disease: pan-airway and systemic inflammatory indices JO - Proc Am Thorac Soc VL - 3 UR - https://doi.org/10.1513/pats.200603-059MS DO - 10.1513/pats.200603-059MS ID - Hurst2006 ER - TY - JOUR AU - Danesh, J. AU - Collins, R. AU - Appleby, P. AU - Peto, R. PY - 1998 DA - 1998// TI - Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease: meta-analyses of prospective studies JO - Jama VL - 279 UR - https://doi.org/10.1001/jama.279.18.1477 DO - 10.1001/jama.279.18.1477 ID - Danesh1998 ER - TY - JOUR AU - Hogg, J. C. AU - Chu, F. AU - Utokaparch, S. AU - Woods, R. AU - Elliott, W. M. AU - Buzatu, L. AU - Cherniack, R. M. AU - Rogers, R. M. AU - Sciurba, F. C. AU - Coxson, H. O. AU - Pare, P. D. PY - 2004 DA - 2004// TI - The nature of small-airway obstruction in chronic obstructive pulmonary disease JO - N Engl J Med VL - 350 UR - https://doi.org/10.1056/NEJMoa032158 DO - 10.1056/NEJMoa032158 ID - Hogg2004 ER - TY - JOUR AU - Delayre-Orthez, C. AU - Becker, J. AU - de Blay, F. AU - Frossard, N. AU - Pons, F. PY - 2005 DA - 2005// TI - Exposure to endotoxins during sensitization prevents further endotoxin-induced exacerbation of airway inflammation in a mouse model of allergic asthma JO - Int Arch Allergy Immunol VL - 138 UR - https://doi.org/10.1159/000088867 DO - 10.1159/000088867 ID - Delayre-Orthez2005 ER - TY - JOUR AU - van der Vaart, H. AU - Koeter, G. H. AU - Postma, D. S. AU - Kauffman, H. F. AU - ten Hacken, N. H. PY - 2005 DA - 2005// TI - First study of infliximab treatment in patients with chronic obstructive pulmonary disease JO - Am J Respir Crit Care Med VL - 172 UR - https://doi.org/10.1164/rccm.200501-147OC DO - 10.1164/rccm.200501-147OC ID - van der Vaart2005 ER - TY - JOUR AU - Rennard, S. I. AU - Fogarty, C. AU - Kelsen, S. AU - Long, W. AU - Ramsdell, J. AU - Allison, J. AU - Mahler, D. AU - Saadeh, C. AU - Siler, T. AU - Snell, P. AU - Korenblat, P. AU - Smith, W. AU - Kaye, M. AU - Mandel, M. AU - Andrews, C. AU - Prabhu, R. AU - Donohue, J. F. AU - Watt, R. AU - Lo, K. H. AU - Schlenker-Herceg, R. AU - Barnathan, E. S. AU - Murray, J. PY - 2007 DA - 2007// TI - The safety and efficacy of infliximab in moderate to severe chronic obstructive pulmonary disease JO - Am J Respir Crit Care Med VL - 175 UR - https://doi.org/10.1164/rccm.200607-995OC DO - 10.1164/rccm.200607-995OC ID - Rennard2007 ER - TY - JOUR AU - Fiorentino, D. F. AU - Zlotnik, A. AU - Mosmann, T. R. AU - Howard, M. AU - O'Garra, A. PY - 1991 DA - 1991// TI - IL-10 inhibits cytokine production by activated macrophages JO - J Immunol VL - 147 ID - Fiorentino1991 ER - TY - JOUR AU - Takanashi, S. AU - Hasegawa, Y. AU - Kanehira, Y. AU - Yamamoto, K. AU - Fujimoto, K. AU - Satoh, K. AU - Okamura, K. PY - 1999 DA - 1999// TI - Interleukin-10 level in sputum is reduced in bronchial asthma, COPD and in smokers JO - Eur Respir J VL - 14 UR - https://doi.org/10.1183/09031936.99.14230999 DO - 10.1183/09031936.99.14230999 ID - Takanashi1999 ER -