Figure 7
From: Non-invasive measurements of exhaled NO and CO associated with methacholine responses in mice
Changes in ECO and AR with inhibition of HO. A. Exhaled CO (ECO) changes with inhibition of heme-oxygenase by tin protoporphyrin (SnPP) without induction of airway inflammation (OVA, i.p.) and with airway inflammation (+OVA aerosol), in C57Bl6 mice, expressed as fraction of naïve (-OVA) controls (dashed line average = 2.3 ppm ECO, as shown in Figure 2A). *P < 0.05 vs. both naïve baseline and respective strain OVA sensitized-only (i.p.) group; n = 4/bar. B. Airway responses (Penh) to methacholine (MCh) aerosol in C57Bl6 mice either naïve (filled square ; n = 11); with airway inflammation (+OVA) +DMSO vehicle (filled circle; n = 6); or with airway inflammation + SnPP/DMSO (inverted filled triangle; n = 4); *P < 0.05 increased vs. naïve at same MCh concentration.