Alterations in ENO and ECO with induction of inflammation. A. Changes in ENO with induction of airway inflammation by OVA treatment in C57Bl6 mice, over duration of sensitization and challenge protocol (3 wk.). Naïve is prior to systemic OVA sensitization injection, pre-challenge is after systemic OVA sensitization booster injection, and post-challenge times are elapsed times after 3rd OVA aerosol challenge. Values are means ± SE for n = 20 mice followed over time, *P < 0.05 as compared to naïve. B. Changes in ECO in same mice as in panel A; *P < 0.05 as compared to naïve.