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Table 4 Effect of PD-123319 on cytokine levels in bronchoalveolar lavage fluid

From: Angiotensin II type 2 receptor antagonist reduces bleomycin-induced pulmonary fibrosis in mice

Day 7

 

TNF-α (pg/ml)

MCP-1 (pg/ml)

TGF-β1 (pg/ml)

 

BLM (n = 8)

21.0 ± 1.9

795.6 ± 109.2

334.8 ± 19.7

 

BLM + PD (n = 8)

13.9 ± 2.6 *

441.8 ± 85.9 *

374.7 ± 46.4

 

PD (n = 8)

5.1 ± 0.0

2.1 ± 0.1

20.7 ± 4.1

Day 14

 

MIP-2 (pg/ml)

TGF-β1 (pg/ml)

 
 

BLM (n = 8)

7.0 ± 1.1

390.0 ± 46.5

 
 

BLM + PD (n = 8)

1.5 ± 0 *

406.1 ± 25.9

 
 

PD (n = 8)

1.5 ± 0

18.0 ± 3.3

 
  1. BLM; bleomycin, PD; PD-123319
  2. Values are expressed as mean ± SEM.
  3. *p < 0.05 as compared to the BLM group.