Skip to main content

Table 3 Effect of PD-123319 on cell components in bronchoalveolar lavage fluid

From: Angiotensin II type 2 receptor antagonist reduces bleomycin-induced pulmonary fibrosis in mice

   

Cell differentiation (× 105/ml)

  

Total cell number (× 105/ml)

Mac

Lym

Neu

Day 7

     
 

BLM (n = 8)

183.3 ± 7.9

69.0 ± 4.2

99.1 ± 6.1

15.3 ± 3.4

 

BLM + PD (n = 8)

118.9 ± 6.1 *

52.8 ± 4.1 *

57.7 ± 3.2 ††

6.6 ± 1.4 **

 

PD (n = 8)

8.0 ± 3.1

6.5 ± 2.6

1.0 ± 0.3

0.5 ± 0.3

Day 14

     
 

BLM (n = 8)

151.8 ± 20.8

57.1 ± 7.6

86.6 ± 14.2

7.9 ± 2.0

 

BLM + PD (n = 8)

84.1 ± 17.1 †

30.5 ± 3.2 **

51.8 ± 15.5 *

1.8 ± 0.5 *

 

PD (n = 8)

8.7 ± 1.3

6.8 ± 0.9

1.3 ± 0.2

0.6 ± 0.3

  1. Mac; Macrophages, Lym; lymphocytes, Neu; neutrophils, BLM; bleomycin, PD; PD-123319
  2. Values are expressed as mean ± SEM.
  3. *p < 0.05, **p < 0.01, †p < 0.005, ††p < 0.001 as compared to the BLM group.