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Table 6 Overlapping chromosomal regions in weighted GSMA for asthma, and the three intermediate phenotypes

From: Meta-analysis of genome-wide linkage studies of asthma and related traits

     ASTHMA BHR TOTAL IGE SPT RESPONSE
BIN (a) GENETIC LOCUS (b) DIST. (cM) (c) PHYS POS. (KBp) (d) p(SR) p(OR) p(SR) p(OR) p(SR) p(OR) p(SR) p(OR)
6 1p13.3-q23.3 142.24–170.84 110103–159125 - - - - 0.06630 0.13155 0.02081 0.22906
7 1q23.3-q31.1 170.84–201.58 159125–185232 - - - - 0.03099 0.14664 0.08924 0.13402
15 2p12-q22.1 101.56–128.41 79617–119705 0.79974 0.00694 0.00574* 0.14743 - - - -
24 3p14.1-q12.3 88.60–117.76 64182–103187 0.02348 0.80059 0.09312 0.17837 - - 0.00298 0.00450*
40 5q5q14.3-q23.2 97.82–131.48 88765–123774 0.71879 0.05004 - - 0.09195 0.08596 - -
41 5q23.2-q34 131.48–164.19 123774–162087 0.06027 0.77886 0.01511 0.09586 0.01890 0.40276 - -
43 6pter-p22.3 0.00–32.62 pter-16854 0.65433 0.03220 - - 0.03276 0.02583 - -
44 6p22.3-p21.1 32.62–65.14 16854–43207 0.03905 0.72593 0.00716* 0.04861 0.00999 0.71984 0.09934 0.16043
45 6p21.1-q15 65.14–99.01 43207–90985 - - 0.07128 0.19832 - - 0.03654 0.12598
46 6q15-q23.2 99.01–131.07 90985–132584 - - 0.09445 0.10925 - - 0.03318 0.18839
50 7p21.1-p14.1 29.28–59.93 19430–40230 0.86218 0.01583 0.03597 0.24658 0.02708 0.41494 - -
55 8pter-p22 0.00–27.40 pter-13111 0.68196 0.01899 - - - - 0.06027 0.07341
71 10q23.33-q26.13 117.42–142.78 95985–123274 0.85805 0.05664 0.16985 0.08106 - - - -
76 11q13.3-q22.3 72.82–98.98 70185–103732 - - 0.12913 0.01652 0.02792 0.22926 - -
77 11q22.3-q24.1 98.98–123.00 103732–122977 - - - - 0.08890 0.12887 0.04276 0.11460
78 11q24.1-qter 123.00–147.77 122977-qter - - 0.00505* 0.46485 - - 0.08072 0.12542
84 12q24.31-qter 139.61–170.60 120806-qter 0.02714 0.65821 - - 0.07175 0.10909 - -
85 13pter-q13.2 0.00–26.87 pter-33636 - - 0.05521 0.18686 0.08835 0.22042 - -
92 14q32.12-qter 105.00–138.18 90647-qter 0.88932 0.00423* - - - - 0.95708 0.07887
108 18q22.1-qter 96.48–126.00 60025-qter - - 0.08190 0.24216 - - 0.96132 0.03480
115 20p11-q13.13 47.52–72.27 21259–46747 0.65424 0.06184 0.10563 0.03503 - - - -
118 21q21.3-qter 25.26–57.77 27903-qter - - 0.20402 0.09140 - - 0.03029 0.28738
  1. Chromosomal regions with p(SR) or p(OR) < 0.1 in two or more weighted GSMA are shown. aBin number from GSMA (1–120 inclusive). bCytogenetic band (Taken from April 2002 Genome Browser, UCSC). cGenetic distance in Marshfield cM (not cumulative). dPhysical position in kilobase pairs (Taken from December 2006 UniSTS, NCBI/Genome Browser, UCSC). *p < 0.000417 = Genome wide significance for linkage, p < 0.0083 = Suggestive for linkage.