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Table 6 Overlapping chromosomal regions in weighted GSMA for asthma, and the three intermediate phenotypes

From: Meta-analysis of genome-wide linkage studies of asthma and related traits

    

ASTHMA

BHR

TOTAL IGE

SPT RESPONSE

BIN (a)

GENETIC LOCUS (b)

DIST. (cM) (c)

PHYS POS. (KBp) (d)

p(SR)

p(OR)

p(SR)

p(OR)

p(SR)

p(OR)

p(SR)

p(OR)

6

1p13.3-q23.3

142.24–170.84

110103–159125

-

-

-

-

0.06630

0.13155

0.02081

0.22906

7

1q23.3-q31.1

170.84–201.58

159125–185232

-

-

-

-

0.03099

0.14664

0.08924

0.13402

15

2p12-q22.1

101.56–128.41

79617–119705

0.79974

0.00694

0.00574*

0.14743

-

-

-

-

24

3p14.1-q12.3

88.60–117.76

64182–103187

0.02348

0.80059

0.09312

0.17837

-

-

0.00298

0.00450*

40

5q5q14.3-q23.2

97.82–131.48

88765–123774

0.71879

0.05004

-

-

0.09195

0.08596

-

-

41

5q23.2-q34

131.48–164.19

123774–162087

0.06027

0.77886

0.01511

0.09586

0.01890

0.40276

-

-

43

6pter-p22.3

0.00–32.62

pter-16854

0.65433

0.03220

-

-

0.03276

0.02583

-

-

44

6p22.3-p21.1

32.62–65.14

16854–43207

0.03905

0.72593

0.00716*

0.04861

0.00999

0.71984

0.09934

0.16043

45

6p21.1-q15

65.14–99.01

43207–90985

-

-

0.07128

0.19832

-

-

0.03654

0.12598

46

6q15-q23.2

99.01–131.07

90985–132584

-

-

0.09445

0.10925

-

-

0.03318

0.18839

50

7p21.1-p14.1

29.28–59.93

19430–40230

0.86218

0.01583

0.03597

0.24658

0.02708

0.41494

-

-

55

8pter-p22

0.00–27.40

pter-13111

0.68196

0.01899

-

-

-

-

0.06027

0.07341

71

10q23.33-q26.13

117.42–142.78

95985–123274

0.85805

0.05664

0.16985

0.08106

-

-

-

-

76

11q13.3-q22.3

72.82–98.98

70185–103732

-

-

0.12913

0.01652

0.02792

0.22926

-

-

77

11q22.3-q24.1

98.98–123.00

103732–122977

-

-

-

-

0.08890

0.12887

0.04276

0.11460

78

11q24.1-qter

123.00–147.77

122977-qter

-

-

0.00505*

0.46485

-

-

0.08072

0.12542

84

12q24.31-qter

139.61–170.60

120806-qter

0.02714

0.65821

-

-

0.07175

0.10909

-

-

85

13pter-q13.2

0.00–26.87

pter-33636

-

-

0.05521

0.18686

0.08835

0.22042

-

-

92

14q32.12-qter

105.00–138.18

90647-qter

0.88932

0.00423*

-

-

-

-

0.95708

0.07887

108

18q22.1-qter

96.48–126.00

60025-qter

-

-

0.08190

0.24216

-

-

0.96132

0.03480

115

20p11-q13.13

47.52–72.27

21259–46747

0.65424

0.06184

0.10563

0.03503

-

-

-

-

118

21q21.3-qter

25.26–57.77

27903-qter

-

-

0.20402

0.09140

-

-

0.03029

0.28738

  1. Chromosomal regions with p(SR) or p(OR) < 0.1 in two or more weighted GSMA are shown. aBin number from GSMA (1–120 inclusive). bCytogenetic band (Taken from April 2002 Genome Browser, UCSC). cGenetic distance in Marshfield cM (not cumulative). dPhysical position in kilobase pairs (Taken from December 2006 UniSTS, NCBI/Genome Browser, UCSC). *p < 0.000417 = Genome wide significance for linkage, p < 0.0083 = Suggestive for linkage.