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Table 3 Weighted GSMA for bronchial hyper-responsiveness (989 pedigrees, n = 4,294)

From: Meta-analysis of genome-wide linkage studies of asthma and related traits

      PROBABILITY
BIN (a) GENETIC LOCUS (b) DISTANCE (cM) (c) PHYSICAL POSITION (KB) (d) SUMMED RANK (SR) p(SR) p(OR)
14 2p16.2-p12 76.34–101.56 54063–79617 532.855 0.02751 0.22094
15 2p12-q22.1 101.56–128.41 79617–119705 576.585 0.00574* 0.14743
16 2q22.1-q23.3 128.41–154.48 119705–151529 518.593 0.04085 0.08859
41 5q23.2-q34 131.48–164.19 123774–162087 551.701 0.01511 0.09586
44 6p22.3-p21.1 32.62–65.14 16854–43207 571.381 0.00716* 0.04861
50 7p21.1-p14.1 29.28–59.93 19430–40230 523.367 0.03597 0.24658
51 7p14.1-q21.11 59.93–91.67 40230–81002 518.746 0.04070 0.19114
52 7q21.11-q31.1 91.67–122.48 81002–109766 461.380 0.13926 0.02065
58 8q13.1-q22 82.84–110.20 67744–99237 468.188 0.12312 0.04443
76 11q13.3-q22.3 72.82–98.98 70185–103732 465.589 0.12913 0.01652
78 11q24.1-qter 123.00–147.77 122977-qter 579.520 0.00505* 0.46485
86 13q13.2-q22.2 26.87–58.54 33636–74875 472.999 0.11255 0.03312
111 19q12-q13.33 52.59–75.41 35843–54589 460.759 0.14078 0.01070
115 20p11-q13.13 47.52–72.27 21259–46747 476.308 0.10563 0.03503
116 20q13.13-qter 72.27–101.22 46747-qter 467.593 0.12448 0.02343
  1. Chromosomal regions with a p(SR) or p(OR) < 0.05 are shown. aBin number from GSMA (1–120 inclusive). bCytogenetic band (Taken from April 2002 Genome Browser, UCSC). cGenetic distance in Marshfield cM (not cumulative). dPhysical position in kilobase pairs (Taken from December 2006 UniSTS, NCBI/Genome Browser, UCSC). *p < 0.000417 = Genome wide significance for linkage, p < 0.0083 = Suggestive for linkage [5].