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Table 2 Weighted GSMA for Asthma (1,267 pedigrees, n = 5,832)

From: Meta-analysis of genome-wide linkage studies of asthma and related traits

     

PROBABILITY

BIN (a)

GENETIC LOCUS (b)

DISTANCE (cM) (c)

PHYSICAL POSITION (KB) (d)

SUMMED RANK (SR)

p(SR)

p(OR)

1

1pter-p36.23

0.00–20.61

pter-9332

376.576

0.68121

0.03775

5

1p31.1-p13.3

113.69–142.24

82867–110103

346.834

0.78259

0.00718*

8

1q31.1-q32

201.58–231.11

185232–210150

347.872

0.77937

0.02791

15

2p12-q22.1

101.56–128.41

79617–119705

341.174

0.79974

0.00694*

18

2q31.1-q34

177.53–206.74

172805–212021

317.985

0.86170

0.03548

20

2q35-qter

233.62–269.07

230618-qter

316.169

0.86603

0.00908

24

3p14.1-q12.3

88.60–117.76

64182–103187

612.921

0.02348

0.80059

31

4p14-q13.3

51.60–78.97

38279–72275

343.939

0.79152

0.00714*

34

4q28.3-q32.1

134.74–159.30

137492–160828

346.992

0.78212

0.01609

43

6pter-p22.3

0.00–32.62

pter-16854

383.747

0.65433

0.03220

44

6p22.3-p21.1

32.62–65.14

16854–43207

592.740

0.03905

0.72593

50

7p21.1-p14.1

29.28–59.93

19430–40230

317.779

0.86218

0.01583

53

7q31.1-q34

122.48–148.11

75216–138638

381.650

0.66230

0.03107

54

7q34-qter

148.11–181.97

138638-qter

313.741

0.87152

0.00536*

55

8pter-p22

0.00–27.40

pter-13111

376.368

0.68196

0.01899

59

8q22-q24.21

110.2–137.92

99237–127416

365.804

0.71999

0.02820

60

8q24.21-qter

137.92–167.90

127416-qter

373.141

0.69378

0.02636

62

9p22.3-p21.1

27.32–53.60

14264–29850

349.926

0.77291

0.03321

68

10p14-q11.21

29.15–62.23

10591–36230

635.659

0.01229

0.79026

75

11p12-q13.3

47.06–72.82

36450–70234

353.473

0.76155

0.02578

79

12pter-p12.1

0.00–24.45

pter-11686

299.278

0.90180

0.00570*

80

12p12.1-p11.21

24.45–53.28

11686–32879

292.228

0.91466

0.00766*

84

12q24.31-qter

139.61–170.60

120806-qter

607.388

0.02714

0.65821

87

13q22.2-q33.1

58.54–85.41

74875–102346

354.469

0.75831

0.04007

89

14pter-q13.1

0.00–40.11

pter- 33529

362.366

0.73182

0.03622

92

14q32.12-qter

105.00-138.18

90647-qter

305.539

0.88932

0.00423*

101

17pter-p12

0.00–25.14

pter-11325

312.768

0.87374

0.00213*

105

18pter-p11

0.00–24.08

pter- 7462

377.842

0.67650

0.04965

113

20pter-p12.3

0.00–21.15

pter-7608

339.111

0.80587

0.00524*

114

20p12.3-p11

21.15–47.52

7608–21259

282.935

0.92982

0.01324

  1. Chromosomal regions with a p(SR) or p(OR) < 0.05 are shown. aBin number from GSMA (1–120 inclusive). bCytogenetic band (Taken from April 2002 Genome Browser, UCSC). cGenetic distance in Marshfield cM (not cumulative). dPhysical position in kilobase pairs (Taken from December 2006 UniSTS, NCBI/Genome Browser, UCSC). *p < 0.000417 = Genome wide significance for linkage, p < 0.0083 = Suggestive for linkage [5].
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Respiratory Research

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