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Table 1 Characteristics of genome-wide linkage studies included in the GSMA

From: Meta-analysis of genome-wide linkage studies of asthma and related traits

  

NUMBER OF.(b)

    

COHORT (REF.)

PHENOTYPES (a)

PED. (AFF/IND.)

MKS.

WF.

MKR MAP (SP.) (c)

STUDY TYPE (d)

ANALYSIS PROGRAM

INCLUDED IN GSMA

Australian [9]

B: Slope (-,0–12 μmol meth.)

80 (25/364)

253

142.267

- (10 cM)

Nonpar.two.

-

B: 23 p-values < 0.05

 

I: Quantitative

      

I: 21 p-values < 0.05

 

S: 2 allergens

      

S: 19 p-values < 0.05

CSGA [33]

A: Quest./Doc diag

79 (200/316)

360

168.642

Marshfield (10 cM)

Nonpar. multi.

Modified GENEHUNTER

A: LOD scores from graphs

German [34]

B: PD20 (Neb, < 8 mg/ml meth.)

97 (200/415)

333

179.725

Modified Genethon (10.7 cM)

Nonpar. multi.

GENEHUNTER, MAP-MAKER/SIBS

B: Complete dataset

French [11]

A: Quest./Meds.

46 (102/210)

254

108.093

– (13 cM)

Nonpar. multi.

GENEHUNTER, SIBPAIR

A: 11 p-values

 

B: Slope (-, meth.)

      

B: 8 p-values

 

I: Quantitative

      

I: 8 p-values

 

S: 11 allergens

      

S: 19 p-values

Icelandic [35]

A: Doc diag./Meds.

175 (596/1134)

976*

413.280

Decode (4 cM)

Nonpar. multi.

ALLEGRO

A: LOD scores from graphs

Dutch [10, 36, 37]

A: Algorithm

200 (-/1159)

366

270.555

Marshfield Weber v8 (10 cM)

Nonpar.

SOLAR, GENEHUNTER

A: Complete dataset

 

B: PD20 (-, < 32 mg/ml hist.)

      

B: Complete dataset

 

I: Quantitative

      

I: Complete dataset

 

S: 16 allergens

      

S: Complete dataset

German [12]

A: Doc diag.

201 (506/867)

364

270.489

Modified Genethon (10 cM)

Nonpar. multi.

MERLIN

A: Complete dataset

 

I: Quantitative/Catagorical

      

I: Complete quantitative dataset

 

S: HDM+

      

S: Complete dataset

Australian [13]

A: Quest./Meds.

202 (169/591)

624

355.032

- (7.1 cM)

Nonpar. multi.

MERLIN, SOLAR

A: Complete dataset

 

B: PD20 (-, < 7.8 μmol hist)

      

B: Complete dataset

 

I: Quantitative

      

I: Complete dataset

 

S: 11 allergens.

      

S: Complete dataset

GAIN [16]

A: Doc diag.

364 (1014/1555)

396*

379.663

Decode (-)

Nonpar. multi.

MERLIN

A: LOD scores from graphs

 

B: PD20 (-, < 8 mg/ml meth.)

      

B: LOD scores from graphs

 

S: 7 allergens

      

S: LOD scores from graphs

  1. (a) A = asthma; B = bronchial hyper-responsiveness (Neb = nebuliser, Dos = dosimeter); I = total serum IgE; S = skin prick test response; Quest = questionnaire; Doc diag = doctor diagnosis; Meds = asthma medication; Meth = methacholine; Hist = histamine; HDM = house dust mite; PD20 = provocation dose resulting in a 20% fall in FEV1. (b) Ped = total genotyped pedigrees; AFF = total genotyped asthmatic cases, Ind = total genotyped individuals; Mks = total autosomal microsatellite markers; Wt = weighting factor. (c) Sp = average marker spacing. (d) Nonpar = nonparametric; Two = two point; Multi = multipoint. (-) = not provided, *number of autosomal markers not given, total number used for weighting.
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Respiratory Research

ISSN: 1465-993X

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