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Table 1 Characteristics of genome-wide linkage studies included in the GSMA

From: Meta-analysis of genome-wide linkage studies of asthma and related traits

   NUMBER OF.(b)     
COHORT (REF.) PHENOTYPES (a) PED. (AFF/IND.) MKS. WF. MKR MAP (SP.) (c) STUDY TYPE (d) ANALYSIS PROGRAM INCLUDED IN GSMA
Australian [9] B: Slope (-,0–12 μmol meth.) 80 (25/364) 253 142.267 - (10 cM) Nonpar.two. - B: 23 p-values < 0.05
  I: Quantitative        I: 21 p-values < 0.05
  S: 2 allergens        S: 19 p-values < 0.05
CSGA [33] A: Quest./Doc diag 79 (200/316) 360 168.642 Marshfield (10 cM) Nonpar. multi. Modified GENEHUNTER A: LOD scores from graphs
German [34] B: PD20 (Neb, < 8 mg/ml meth.) 97 (200/415) 333 179.725 Modified Genethon (10.7 cM) Nonpar. multi. GENEHUNTER, MAP-MAKER/SIBS B: Complete dataset
French [11] A: Quest./Meds. 46 (102/210) 254 108.093 – (13 cM) Nonpar. multi. GENEHUNTER, SIBPAIR A: 11 p-values
  B: Slope (-, meth.)        B: 8 p-values
  I: Quantitative        I: 8 p-values
  S: 11 allergens        S: 19 p-values
Icelandic [35] A: Doc diag./Meds. 175 (596/1134) 976* 413.280 Decode (4 cM) Nonpar. multi. ALLEGRO A: LOD scores from graphs
Dutch [10, 36, 37] A: Algorithm 200 (-/1159) 366 270.555 Marshfield Weber v8 (10 cM) Nonpar. SOLAR, GENEHUNTER A: Complete dataset
  B: PD20 (-, < 32 mg/ml hist.)        B: Complete dataset
  I: Quantitative        I: Complete dataset
  S: 16 allergens        S: Complete dataset
German [12] A: Doc diag. 201 (506/867) 364 270.489 Modified Genethon (10 cM) Nonpar. multi. MERLIN A: Complete dataset
  I: Quantitative/Catagorical        I: Complete quantitative dataset
  S: HDM+        S: Complete dataset
Australian [13] A: Quest./Meds. 202 (169/591) 624 355.032 - (7.1 cM) Nonpar. multi. MERLIN, SOLAR A: Complete dataset
  B: PD20 (-, < 7.8 μmol hist)        B: Complete dataset
  I: Quantitative        I: Complete dataset
  S: 11 allergens.        S: Complete dataset
GAIN [16] A: Doc diag. 364 (1014/1555) 396* 379.663 Decode (-) Nonpar. multi. MERLIN A: LOD scores from graphs
  B: PD20 (-, < 8 mg/ml meth.)        B: LOD scores from graphs
  S: 7 allergens        S: LOD scores from graphs
  1. (a) A = asthma; B = bronchial hyper-responsiveness (Neb = nebuliser, Dos = dosimeter); I = total serum IgE; S = skin prick test response; Quest = questionnaire; Doc diag = doctor diagnosis; Meds = asthma medication; Meth = methacholine; Hist = histamine; HDM = house dust mite; PD20 = provocation dose resulting in a 20% fall in FEV1. (b) Ped = total genotyped pedigrees; AFF = total genotyped asthmatic cases, Ind = total genotyped individuals; Mks = total autosomal microsatellite markers; Wt = weighting factor. (c) Sp = average marker spacing. (d) Nonpar = nonparametric; Two = two point; Multi = multipoint. (-) = not provided, *number of autosomal markers not given, total number used for weighting.