Table 1 Characteristics of genome-wide linkage studies included in the GSMA
From: Meta-analysis of genome-wide linkage studies of asthma and related traits
| NUMBER OF.(b) | ||||||||
|---|---|---|---|---|---|---|---|---|
| COHORT (REF.) | PHENOTYPES (a) | PED. (AFF/IND.) | MKS. | WF. | MKR MAP (SP.) (c) | STUDY TYPE (d) | ANALYSIS PROGRAM | INCLUDED IN GSMA |
| Australian [9] | B: Slope (-,0–12 μmol meth.) | 80 (25/364) | 253 | 142.267 | - (10 cM) | Nonpar.two. | - | B: 23 p-values < 0.05 |
| I: Quantitative | I: 21 p-values < 0.05 | |||||||
| S: 2 allergens | S: 19 p-values < 0.05 | |||||||
| CSGA [33] | A: Quest./Doc diag | 79 (200/316) | 360 | 168.642 | Marshfield (10 cM) | Nonpar. multi. | Modified GENEHUNTER | A: LOD scores from graphs |
| German [34] | B: PD20 (Neb, < 8 mg/ml meth.) | 97 (200/415) | 333 | 179.725 | Modified Genethon (10.7 cM) | Nonpar. multi. | GENEHUNTER, MAP-MAKER/SIBS | B: Complete dataset |
| French [11] | A: Quest./Meds. | 46 (102/210) | 254 | 108.093 | – (13 cM) | Nonpar. multi. | GENEHUNTER, SIBPAIR | A: 11 p-values |
| B: Slope (-, meth.) | B: 8 p-values | |||||||
| I: Quantitative | I: 8 p-values | |||||||
| S: 11 allergens | S: 19 p-values | |||||||
| Icelandic [35] | A: Doc diag./Meds. | 175 (596/1134) | 976* | 413.280 | Decode (4 cM) | Nonpar. multi. | ALLEGRO | A: LOD scores from graphs |
| Dutch [10, 36, 37] | A: Algorithm | 200 (-/1159) | 366 | 270.555 | Marshfield Weber v8 (10 cM) | Nonpar. | SOLAR, GENEHUNTER | A: Complete dataset |
| B: PD20 (-, < 32 mg/ml hist.) | B: Complete dataset | |||||||
| I: Quantitative | I: Complete dataset | |||||||
| S: 16 allergens | S: Complete dataset | |||||||
| German [12] | A: Doc diag. | 201 (506/867) | 364 | 270.489 | Modified Genethon (10 cM) | Nonpar. multi. | MERLIN | A: Complete dataset |
| I: Quantitative/Catagorical | I: Complete quantitative dataset | |||||||
| S: HDM+ | S: Complete dataset | |||||||
| Australian [13] | A: Quest./Meds. | 202 (169/591) | 624 | 355.032 | - (7.1 cM) | Nonpar. multi. | MERLIN, SOLAR | A: Complete dataset |
| B: PD20 (-, < 7.8 μmol hist) | B: Complete dataset | |||||||
| I: Quantitative | I: Complete dataset | |||||||
| S: 11 allergens. | S: Complete dataset | |||||||
| GAIN [16] | A: Doc diag. | 364 (1014/1555) | 396* | 379.663 | Decode (-) | Nonpar. multi. | MERLIN | A: LOD scores from graphs |
| B: PD20 (-, < 8 mg/ml meth.) | B: LOD scores from graphs | |||||||
| S: 7 allergens | S: LOD scores from graphs | |||||||