Circulating alpha1-antitrypsin in the general population: Determinants and association with lung function

Respiratory Research

Table 7 Adjusted* mean AAT serum levels in women by menopausal status and hormone intake

	Predictor	Number of subjects	AAT (SE) (g/L) no CRP adjustment	AAT (SE) (g/L) CRP adjustment
Menopausal status in women without hormonal treatment^¶,†:	Premenopausal	806	1.277 (0.007)	1.282 (0.007)
	Postmenopausal	848	1.256 (0.007)	1.252 (0.006)
			p = 0.038	p = 0.003
Oral contraceptives in premenopausal women:	no OC use	640	1.278 (0.007)	1.288 (0.007)
	use of OC	166	1.520 (0.016)	1.470 (0.016)
			p < 0.001	p < 0.001
Hormone replacement in postmenopausal women:	no use of HRT	324	1.207 (0.015)	1.216 (0.014)
	use of HRT	524	1.272 (0.015)	1.268 (0.014)
			p < 0.001	p < 0.001

* adjusted for BMI, age, active and passive smoking, alcohol consumption, systolic blood pressure and study area ^¶perimenopausal women (n = 82) and women with unclear/missing information on hormonal use (n = 243) were excluded; ^†not adjusted for age due to co-linearity between age and menopausal status; OC = oral contraception; HRT = hormone replacement therapy;

ISSN: 1465-993X