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Table 2 Adjusted* mean AAT serum levels by age, gender, anthropometrics, blood pressure, crp, and lifestyle variables (n = 5187)

From: Circulating alpha1-antitrypsin in the general population: Determinants and association with lung function

   Number of subjects AAT (SE) (g/L), no CRP adjustment AAT (SE) (g/L), CRP adjustment
Gender Men 2518 1.203 (0.004) 1.215 (0.004)
  Women 2669 1.305 (0.004) 1.293 (0.004)
    p < 0.001 p < 0.001
Age Quartiles (years):    
Men <43 630 1.194 (0.007) 1.195 (0.007)
  <53 629 1.200 (0.007) 1.205 (0.006)
  <61 630 1.208 (0.007) 1.208 (0.006)
  <73 629 1.239 (0.007) 1.233 (0.007)
    p trend < 0.001 p trend = 0.001
Premenopausal women¶,† <38 202 1.314 (0.013) 1.312 (0.012)
  <43 201 1.284 (0.013) 1.284 (0.012)
  <50 202 1.278 (0.013) 1.281 (0.012)
  <55 201 1.227 (0.013) 1.227 (0.012)
    p trend < 0.001 p trend < 0.001
Postmenopausal women¶,† <55 212 1.221 (0.014) 1.221 (0.013)
  <61 212 1.255 (0.013) 1.261 (0.012)
  <67 212 1.281 (0.013) 1.276 (0.013)
  <73 212 1.275 (0.013) 1.273 (0.013)
    p trend 0.05 p trend 0.07
BMI Quartiles (kg/m2):    
  <22.79 1338 1.284 (0.005) 1.306 (0.005)
  <25.38 1349 1.250 (0.005) 1.257 (0.005)
  <28.36 1287 1.241 (0.005) 1.237 (0.005)
  ≥28.36 1213 1.247 (0.005) 1.218 (0.005)
    p trend = 0.003 p trend < 0.001
Systolic blood pressure Quartiles (mmHg):    
  <114 1342 1.240 (0.006) 1.244 (0.005)
  <126 1279 1.252 (0.005) 1.254 (0.005)
  <139 1304 1.260 (0.005) 1.259 (0.005)
  ≥139 1262 1.272 (0.006) 1.266 (0.005)
    p trend < 0.001 p trend 0.002
Tobacco exposure‡ Never smokers/ETS- 2121 1.236 (0.005) 1.238 (0.004)
  Never smokers/ETS+ 388 1.260 (0.010) 1.269 (0.009)
  Former smokers/ETS- 1188 1.238 (0.006) 1.240 (0.005)
  Former smokers/ETS+ 312 1.249 (0.011) 1.249 (0.010)
  Current smokers, <15 cig/d) 515 1.284 (0.008) 1.285 (0.008)
  Current smokers, ≥15 cig/d) 662 1.328 (0.009) 1.314 (0.008)
    p trend < 0.0001 p trend < 0.0001
Alcohol intake <1 drink per day 4069 1.261 (0.003) 1.262 (0.003)
  ≥1 drink per day 1118 1.235 (0.006) 1.234 (0.007)
    p < 0.001 p < 0.001
CRP Quartiles (mg/l):    
  <0.6 1506 1.182 -
  <1.1 1202 1.227 -
  <2.2 1232 1.268 -
  ≥ 2.2 1247 1.360 -
    P trend < 0.00001  
  1. *adjusted for age, gender, smoking status, alcohol intake, BMI, systolic blood pressure and study area women taking oral contraceptives (n = 166), hormone replacement (n = 524), with perimenopausal status (n = 82), and unclear/missing hormonal status (n = 243) were excluded; p(interaction) pre-versus postmenopausal women <0.001; n = 5186, due to 1 former smoker with missing ETS exposure; ETS = environmental tobacco exposure