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Table 2 Adjusted* mean AAT serum levels by age, gender, anthropometrics, blood pressure, crp, and lifestyle variables (n = 5187)

From: Circulating alpha1-antitrypsin in the general population: Determinants and association with lung function

  

Number of subjects

AAT (SE) (g/L), no CRP adjustment

AAT (SE) (g/L), CRP adjustment

Gender

Men

2518

1.203 (0.004)

1.215 (0.004)

 

Women

2669

1.305 (0.004)

1.293 (0.004)

   

p < 0.001

p < 0.001

Age

Quartiles (years):

   

Men

<43

630

1.194 (0.007)

1.195 (0.007)

 

<53

629

1.200 (0.007)

1.205 (0.006)

 

<61

630

1.208 (0.007)

1.208 (0.006)

 

<73

629

1.239 (0.007)

1.233 (0.007)

   

p trend < 0.001

p trend = 0.001

Premenopausal women¶,†

<38

202

1.314 (0.013)

1.312 (0.012)

 

<43

201

1.284 (0.013)

1.284 (0.012)

 

<50

202

1.278 (0.013)

1.281 (0.012)

 

<55

201

1.227 (0.013)

1.227 (0.012)

   

p trend < 0.001

p trend < 0.001

Postmenopausal women¶,†

<55

212

1.221 (0.014)

1.221 (0.013)

 

<61

212

1.255 (0.013)

1.261 (0.012)

 

<67

212

1.281 (0.013)

1.276 (0.013)

 

<73

212

1.275 (0.013)

1.273 (0.013)

   

p trend 0.05

p trend 0.07

BMI

Quartiles (kg/m2):

   
 

<22.79

1338

1.284 (0.005)

1.306 (0.005)

 

<25.38

1349

1.250 (0.005)

1.257 (0.005)

 

<28.36

1287

1.241 (0.005)

1.237 (0.005)

 

≥28.36

1213

1.247 (0.005)

1.218 (0.005)

   

p trend = 0.003

p trend < 0.001

Systolic blood pressure

Quartiles (mmHg):

   
 

<114

1342

1.240 (0.006)

1.244 (0.005)

 

<126

1279

1.252 (0.005)

1.254 (0.005)

 

<139

1304

1.260 (0.005)

1.259 (0.005)

 

≥139

1262

1.272 (0.006)

1.266 (0.005)

   

p trend < 0.001

p trend 0.002

Tobacco exposure‡

Never smokers/ETS-

2121

1.236 (0.005)

1.238 (0.004)

 

Never smokers/ETS+

388

1.260 (0.010)

1.269 (0.009)

 

Former smokers/ETS-

1188

1.238 (0.006)

1.240 (0.005)

 

Former smokers/ETS+

312

1.249 (0.011)

1.249 (0.010)

 

Current smokers, <15 cig/d)

515

1.284 (0.008)

1.285 (0.008)

 

Current smokers, ≥15 cig/d)

662

1.328 (0.009)

1.314 (0.008)

   

p trend < 0.0001

p trend < 0.0001

Alcohol intake

<1 drink per day

4069

1.261 (0.003)

1.262 (0.003)

 

≥1 drink per day

1118

1.235 (0.006)

1.234 (0.007)

   

p < 0.001

p < 0.001

CRP

Quartiles (mg/l):

   
 

<0.6

1506

1.182

-

 

<1.1

1202

1.227

-

 

<2.2

1232

1.268

-

 

≥ 2.2

1247

1.360

-

   

P trend < 0.00001

 
  1. *adjusted for age, gender, smoking status, alcohol intake, BMI, systolic blood pressure and study area women taking oral contraceptives (n = 166), hormone replacement (n = 524), with perimenopausal status (n = 82), and unclear/missing hormonal status (n = 243) were excluded; †p(interaction) pre-versus postmenopausal women <0.001; ‡ n = 5186, due to 1 former smoker with missing ETS exposure; ETS = environmental tobacco exposure
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Respiratory Research

ISSN: 1465-993X

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