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Table 5 Estimated* 10 year change in FVC (mL), FEV1 (mL) and FEV1/FVC (%) across different categories of change in BMI within baseline BMI quartiles

From: Longitudinal association of body mass index with lung function: The CARDIA Study

 

Quartiles of baseline BMI *+

 

<21.3 kg/m 2

21.3–<23.4 kg/m 2

23.4–<26.4 kg/m 2

≥ 26.4 kg/m 2

2, 5 and 10 year FVC change (p interaction < 0.0001)

 

Categories of Change in BMI

Q1

Q2

Q3

Q4

≤ 0 kg/m2

5 (-14 – 24)

32 (14 – 49)

49 (32 – 67)

22 (4 – 40)

0.1–0.9 kg/m2

15 (1 – 30)

22 (8 – 37)

22 (8 – 37)

15 (0 – 31)

1–2.4 kg/m2

53 (38 – 67)

19 (4 – 33)

-13 (-27 – 2)

-63 (-80 – -46)

2.5–5.9 kg/m2

65 (46 – 83)

1 (-17 – 18)

-69 (-85 – -53)

-146 (-161 – -130)

≥ 6 kg/m2

5 (-37 – 46)

-96 (-132 – -60)

-178 (-208 – -148)

-264 (-286 – -243)

2, 5, and 10 year FEV 1 change (p interaction < 0.0001)

    

Categories of Change in BMI

Q1

Q2

Q3

Q4

≤ 0 kg/m2

-38 (-56 – -19)

-18 (-35 – -2)

-5 (-21 – 11)

-11 (-22 – 6)

0.1–0.9 kg/m2

-31 (-45 – -17)

-24 (-38 – -10)

-22 (-36 – -8)

-30 (-45 – -16)

1–2.4 kg/m2

-30 (-44 – -16)

-60 (-73 – -46)

-66 (-80 – -52)

-81 (-97 – -64)

2.5–5.9 kg/m2

-54 (-71 – -36)

-95 (-111 – -78)

-121 (-137 – -106)

-136 (-151 – -121)

≥ 6 kg/m2

-110 (-149 – -70)

-147 (-181 – -112)

-201 (-230 – -173)

-216 (-236 – -195)

2, 5, and 10 year FEV 1 /FVC change (p interaction < 0.0001)

    

Categories of Change in BMI

Q1

Q2

Q3

Q4

≤ 0 kg/m2

-0.96 (-1.30 – -0.63)

-1.03 (-1.33 – -0.74)

-0.99 (-1.29 – -0.70)

-0.70 (-1.01 – -0.40)

0.1–0.9 kg/m2

-1.03 (-1.28 – -0.78)

-1.03 (-1.28 – -0.78)

-1.01 (-1.26 – -0.75)

-1.01 (-1.27 – -0.74)

1–2.4 kg/m2

-1.85 (-2.10 – -1.61)

-1.71 (-1.95 – -1.46)

-1.24 (-1.49 – -0.98)

-0.68 (-0.97 – -0.39)

2.5–5.9 kg/m2

-2.59 (-2.91 – -2.28)

-2.18 (-2.47 – -1.89)

-1.55 (-1.82 – -1.27)

-0.51 (-0.78 – -0.25)

≥ 6 kg/m2

-3.30 (-4.01 – -2.59)

-2.10 (-2.72 – -1.48)

-1.60 (-2.12 – -1.08)

-0.11 (-0.48 – 0.26)

  1. * Estimated FVC, FEV1 and FEV1/FVC were obtained from a repeated measures linear regression model that evaluated the change in lung function from baseline over 2, 5 and 10 years across different baseline BMI quartiles after adjusting for current age, (current age)2, race, gender, study center, height, (height)2, age group, smoking status, asthma status, and alcohol intake all measured at baseline (year 0), change in smoking status, change in physical activity and change in alcohol intake (all over 2, 5 and 10 years).
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Respiratory Research

ISSN: 1465-993X

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