Longitudinal association of body mass index with lung function: The CARDIA Study

Respiratory Research

Table 4 Estimated* 10 year change in FVC (mL), FEV₁ (mL) and FEV₁/FVC (%) across baseline BMI quartiles, overall and among never smokers who did not have asthma at baseline or during the study

Quartiles of baseline BMI	10-year Change in lung function value
All participants	FVC	FEV1	FEV1/FVC
<21.2 kg/m²	71 (-43 – 184)	60 (-38 – 159)	-0.07% (-1.40% – 1.26%)
21.3–<23.4 kg/m²	19 (-94 – 133)	18 (-79 – 116)	0.29% (-1.03% – 1.62%)
23.4–<26.4 kg/m²	-72 (-186 – 41)	-28 (-125 – 70)	1.00% (-0.33% – 2.33%)
≥ 26.4 kg/m²	-185 (-298 – -71)	-64 (-161 – 34)	2.03% (0.71% – 3.36%)
p trend	<0.0001	<0.0001	<0.0001
Never smoker, never asthma
<21.2 kg/m²	129 (-37 – 294)	76 (-62 – 215)	-0.84% (-2.63% – 0.95%)
21.3–<23.4 kg/m²	78 (-87 – 244)	29 (-109 – 168)	-0.60% (-2.39% – 1.18%)
23.4–<26.4 kg/m²	-18 (-184 – 147)	-28 (-166 – 111)	0.05% (-1.73% – 1.84%)
≥ 26.4 kg/m²	-138 (-304 – 27)	-47 (-186 – 91)	1.60% (-0.19% – 3.39%)
p trend	<0.0001	<0.0001	<0.0001

* Estimated FVC, FEV₁ and FEV₁/FVC were obtained using a repeated measures linear regression model to estimate lung function values over a 10 year period across baseline BMI quartiles after adjusting for current age, (current age)², race, gender, study center, height, (height)², baseline age group, smoking status, asthma status, physical activity and alcohol intake all measured at baseline (year 0).

ISSN: 1465-993X