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Figure 3 | Respiratory Research

Figure 3

From: Sequestration and homing of bone marrow-derived lineage negative progenitor cells in the lung during pneumococcal pneumonia

Figure 3

Frequency of labeled donor cells in bone marrow. BM cells were harvested from recipients which were sacrificed at 2 or 24 hours after the cell transfusion. The frequency of labeled cells was measured by flow cytometry and the total number of labeled donor cells in recipients' bone marrow was calculated. The results are shown as percentages of total number of transfused donor cells. In the whole BM cell transfusion experiment (A), there was an upward trend in the pneumonia group as compared to control (7.7 ± 0.6% vs. 6.1 ± 0.5%, P = 0.09) at 2 hours post-transfusion, although by 24 hours, the number of labeled cells equalized and there was no significant difference between the groups (P = 0.81). In the Lin- progenitor cell transfusion model (B), there was no significant difference in the proportion of labeled cells between the control and pneumonia groups (10.1 ± 1.5% vs. 12.9 ± 1.2%, P = 0.19) at 2 hours. After 24 hours, the ratio of donor cells in the pneumonia group increased significantly as compared to control (P < 0.001) and the previous timepoint (P = 0.006). Data is shown as mean ± SE; n = 6 (control group for each timepoint) and n = 7 (pneumonia group for each timepoint). **P < 0.01.

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