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Table 1 Up-regulated genes in IPAH vs. controls: at least 1.3 fold up-regulated in GCOS and GSS

From: Peripheral blood B lymphocytes derived from patients with idiopathic pulmonary arterial hypertension express a different RNA pattern compared with healthy controls: a cross sectional study

Gene Name Fold Change Description Gene Symbol GO Biological Process Description
205033_s_at 30.76 defensin, alpha 1, myeloid-related sequence DEFA1 /// DEFA3 xenobiotic metabolism /// response to virus /// defense response to bacteria /// defense response to fungi /// defense response /// response to pest, pathogen or parasite
204351_at 15.05 S100 calcium binding protein P S100P endothelial cell migration
232629_at 10.03 prokineticin 2 PROK2 activation of MAPK activity /// angiogenesis /// anti-apoptosis /// chemotaxis /// inflammatory response /// elevation of cytosolic calcium ion concentration /// neuropeptide signaling pathway /// spermatogenesis /// cell proliferation /// sensory percept
202917_s_at 5.678 S100 calcium binding protein A8 (calgranulin A) S100A8 inflammatory response
211654_x_at 5.479 major histocompatibility complex, class II, DQ beta 1 HLA-DQB1 immune response /// immune response /// antigen presentation, exogenous antigen /// antigen processing, exogenous antigen via MHC class II
209773_s_at 5.435 ribonucleotide reductase M2 polypeptide RRM2 DNA replication /// deoxyribonucleoside diphosphate metabolism /// DNA replication
220005_at 5.189 G protein-coupled receptor 86 P2RY13 signal transduction /// G-protein coupled receptor protein signaling pathway
225987_at 4.787 likely ortholog of mouse tumor necrosis-alpha-induced adipose-related protein STEAP4 fat cell differentiation /// electron transport
209773_s_at 5.435 ribonucleotide reductase M2 polypeptide RRM2 DNA replication /// deoxyribonucleoside diphosphate metabolism /// DNA replication
220005_at 5.189 G protein-coupled receptor 86 P2RY13 signal transduction /// G-protein coupled receptor protein signaling pathway
225987_at 4.787 likely ortholog of mouse tumor necrosis-alpha-induced adipose-related protein STEAP4 fat cell differentiation /// electron transport
212999_x_at 4.322 major histocompatibility complex, class II, DQ beta 1 HLA-DQB1 immune response /// immune response /// antigen presentation, exogenous antigen /// antigen processing, exogenous antigen via MHC class II
220167_s_at 3.448 TP53TG3 protein TP53TG3 ---
223204_at 3.429 hypothetical protein DKFZp434L142 DKFZp434L142 ---
213975_s_at 2.807 lysozyme (renal amyloidosis) LYZ /// LILRB1 carbohydrate metabolism /// cell wall catabolism /// cytolysis /// defense response to bacteria /// immune response /// response to virus /// tRNA aminoacylation for protein translation
209514_s_at 2.779 RAB27A, member RAS oncogene family RAB27A intracellular protein transport /// small GTPase mediated signal transduction /// protein transport
228898_s_at 2.13 similar to putative NADH oxidoreductase complex I subunit homolog. SMARCB1 chromatin remodeling /// transcription /// regulation of transcription from RNA polymerase II promoter /// cell cycle /// DNA integration /// negative regulation of progression through cell cycle /// retroviral genome replication /// regulation of transcription
201310_s_at 2.039 chromosome 5 open reading frame 13 C5orf13 ---
227724_at 1.956 hypothetical gene supported by AK091744 LOC439987 ---
208704_x_at 1.92 amyloid beta (A4) precursor-like protein 2 APLP2 G-protein coupled receptor protein signaling pathway
222688_at 1.916 yf40c04.s1 Soares fetal liver spleen 1NFLS Homo sapiens cDNA clone IMAGE:129318 3', mRNA sequence. PHCA protein biosynthesis /// ceramide metabolism
214864_s_at 1.852 glyoxylate reductase/hydroxypyruvate reductase GRHPR L-serine biosynthesis /// excretion /// metabolism /// metabolism
230126_s_at 1.774 KIAA0876 protein JMJD2B regulation of transcription, DNA-dependent
207426_s_at 1.774 tumor necrosis factor (ligand) superfamily, member 4 (tax-transcriptionally activated glycoprotein 1, 34kDa) TNFSF4 immune response /// signal transduction /// cell-cell signaling /// positive regulation of cell proliferation
212998_x_at 1.759 major histocompatibility complex, class II, DQ beta 2 HLA-DQB2 immune response /// immune response /// antigen presentation, exogenous antigen /// antigen processing, exogenous antigen via MHC class II
212495_at 1.745 KIAA0876 protein JMJD2B regulation of transcription, DNA-dependent
221581_s_at 1.676 Williams-Beuren syndrome chromosome region 5 LAT2 intracellular signaling cascade /// calcium-mediated signaling /// immune response /// mast cell degranulation /// B cell activation
208248_x_at 1.672 amyloid beta (A4) precursor-like protein 2 APLP2 G-protein coupled receptor protein signaling pathway
226456_at 1.66 hypothetical protein MGC24665 MGC24665 ---
208703_s_at 1.651 amyloid beta (A4) precursor-like protein 2 APLP2 G-protein coupled receptor protein signaling pathway
212496_s_at 1.625 KIAA0876 protein JMJD2B regulation of transcription, DNA-dependent
223445_at 1.588 dystrobrevin binding protein 1 DTNBP1 organelle organization and biogenesis /// sensory perception /// visual perception /// response to stimulus
225593_at 1.578 U7 snRNP-specific Sm-like protein LSM10 LSM10 nuclear mRNA splicing, via spliceosome /// mRNA processing
223361_at 1.537 similar to HSPC280 C6orf115 ---
224948_at 1.477 mitochondrial ribosomal protein S24 MRPS24 ---