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Figure 1 | Respiratory Research

Figure 1

From: Endothelial cell apoptosis in chronically obstructed and reperfused pulmonary artery

Figure 1

A: Proportion of endothelial cells undergoing apoptosis in the proximal pulmonary arteries. The proportion increased significantly from 8.1 ± 1.8% in sham animals (S) to 14.8 ± 1% 5 weeks after ligation of the left pulmonary artery (L), peaked at 42.9 ± 1.9% 2 days after reperfusion (AR), and returned to 9.8 ± 1.6% 5 weeks after reperfusion (CR). *p < 0.0001 versus sham, **p < 0.0001 versus all other groups. S: sham group; L: ligated group; AR: acute reperfusion group; CR: chronic reperfusion group. B: TUNEL staining of endothelial cells in the sham group, ligated group, acute reperfusion group after 2 days, and chronic reperfusion group after 5 weeks. Apoptotic cells are yellow. S: sham group; L: ligated group; AR: acute reperfusion group; CR: chronic reperfusion group. C: Caspase-3 activity in the proximal pulmonary arteries. Caspase-3 activity increased from 0.019 ± 0.008 mg/ml in sham animals (S) to 0.035 ± 0.015 mg/ml 5 weeks after ligation of the left pulmonary artery (L), peaked at 0.101 ± 0.028 mg/ml 2 days after reperfusion (AR), and returned to 0.034 ± 0.015 mg/ml after 5 weeks of reperfusion (CR). *p < 0.0001 versus sham.

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