Figure 3
From: Remodeling of extra-bronchial lung vasculature following allergic airway inflammation
Photomicrographs illustrating vascular remodeling following 7 days of allergen exposure. Vascular remodeling involves smooth muscle (α-smooth muscle actin: red), fibroblasts (procollagen I: brown) and myofibroblasts (here defined as solitary cells co-positive for α-smooth muscle actin and procollagen I: co-positive), in both small solitary (A-B) and mid-sized solitary (C-D) vessels. In comparison with controls (A and C) vessels from OVA exposed animals (B and D) show a significantly increased smooth muscle area as well as increased number of myofibroblasts (arrows) and procollagen I-producing cells. Vascular lumen is indicated by stars. Scale bar represents 50 μm.