Figure 1

Myosin heavy chain isoform distribution, analyzed by western blot, in the costal diaphragm from severe COPD and non-COPD patients. Diaphragm from COPD patients contains a higher proportion of slow myosin heavy chain isoform and lower proportions of IIA and IIX isoforms compared to the diaphragm from non-COPD patients. Reproduced from Levine et al. [15] with permission.