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Table 3 Risk factors according to univariate survival analyses in the total population of patients (n = 231).

From: Health-related quality of life and long-term prognosis in chronic hypercapnic respiratory failure: a prospective survival analysis

Variable

Median (Quartile)

p-value§

HR

95%-CI of HR

Disease category +

-

< 0.001

0.266

0.139–0.508

Sex (m/f)

-

0.091

1.803

0.911–3.568

Age (yrs)

65.4 (57.1; 70.4)

0.074

1.745

0.940–3.238

BMI (kg/m2)

31.6 (26.9; 38.2**)

0.006

0.420

0.223–0.792

Leukocytes (103/μL)

8.6 (6.6*; 10.6*)

0.002

2.745

1.414–5.332

BE (mmol/L)

3.70 (2.00; 5.50***)

0.027

1.991

1.067–3.715

FEV1 (L)

1.03 (0.76; 1.59*)

< 0.001

0.267

0.131–0.544

FEV1 (%pred)

42.1 (31.9**; 63.5*)

0.001

0.351

0.179–0.686

IVC (L)

1.84 (1.38; 2.56)

0.112

0.617

0.338–1.125

IVC (%pred)

60.8 (45.9; 76.1*)

0.205

0.665

0.352–1.255

FEV/IVC (%)

62.0 (47.0; 76.0)

0.001

0.950

0.920–0.981

SRI-RC

62.5 (46.9*; 75.0**)

< 0.001

0.280

0.142–0.554

SRI-PF

50.0 (33.3*; 70.0*)

0.002

0.379

0.198–0.724

SRI-AS

64.3 (53.6; 75.0)

0.124

0.629

0.342–1.142

SRI-SR

75.0 (58.3**; 83.3*)

0.002

0.381

0.202–0.718

SRI-AX

65.0 (45.0*; 80.0*)

0.006

0.420

0.223–0.793

SRI-PW

61.1 (50.0**; 77.8)

0.012

0.464

0.251–0.857

SRI-SF

56.3 (40.6*; 75.0*)

0.002

0.374

0.198–0.705

SRI-SS

60.0 (49.7**; 74.9*)

< 0.001

0.262

0.129–0.530

  1. Median values and quartiles are given for the total population, as values were not normally distributed due to the pooling of groups.+ COPD vs. non-COPD. § according to univariate survival analyses (log-rank) using the respective median value. Additionally, 25th and 75th percentiles were used. *p < 0.05; **p < 0.01; ***p < 0.001. Definition of abbreviations: HR = hazard ratio for survival; CI = Confidence interval; BMI = body-mass index; BE = base excess; FEV1 = forced expiratory volume in one second; IVC = inspiratory vital capacity; SRI = Severe Respiratory Insufficiency Questionnaire; RC = Respiratory Complaints; PF = Physical Functioning; AS = Attendant symptoms and Sleep; SR = Social Relationships; AX = Anxiety; WB = Psychological Well-being; SF = Social Functioning. SS = Summary Score.