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Figure 3 | Respiratory Research

Figure 3

From: Pioglitazone is as effective as dexamethasone in a cockroach allergen-induced murine model of asthma

Figure 3

PIO reduces pulmonary cytokine and chemokine levels as effectively as DEX. PIO, DEX, or vehicle (Veh) was administered daily (days 14–21). Twenty-four h following the final CRA challenge, cytokine levels were measured (by ELISA unless otherwise noted) in homogenized lung tissue from 8 mice/group. A. TH2 cytokines IL-4 and IL-5. B Cytokines TNF-α and TGF-β. TGF-β expression was measured using quantitative PCR analysis of total RNA from lung tissue. The ratio of TGF-β expression to β-actin expression in control animals was assigned a value of 1. C. Chemokines eotaxin, RANTES, and MIP3-α. MIP3-α expression was measured using quantitative PCR analysis of total RNA from lung tissue. The ratio of MIP3-α expression to β-actin expression in control animals was assigned a value of 1. *P < 0.05 compared to vehicle treatment.

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