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Table 3 Analysis of glucocorticoid receptor genotypes and longitudinal trends for FEV1 and FVC

From: Glucocorticoid receptor gene polymorphisms associated with progression of lung disease in young patients with cystic fibrosis

   Total population F508del/F508del patients
  Genotype Y6 (± SD) k (± SD) p Y6 (± SD) k (± SD) p
FEV 1
TthIII CC 95.5 (± 2.9) -2.5 (± 0.5) 0.7 89.2 (± 4.1) -2.2 (± 0.7) 0.4
  CT 96.2 (± 4.1) -2.9 (± 0.7)   98.7 (± 5.4) -3.8 (± 0.9)  
  TT 88.8 (± 6.7) -1.6 (± 1.1)   94.4 (± 8.4) -2.2 (± 1.3)  
ER22/23EK GG 95.2 (± 11.2) -2.6 (± 1.7) 0.4 94.6 (± 21.4) -3.0 (± 2.9) 0.7
  AA + AG 92.6 (± 11.0) -0.5 (± 1.7)   90.4 (± 21.2) -0.9 (± 2.8)  
N363S AA 95.5 (± 7.3) -2.6 (± 1.4) 0.5 95.3 ± (9.9) -3.0 (± 2.2) 0.5
  GG + AG 89.9 (± 7.0) -2.9 (± 1.4)   85.3 ± (9.6) -3.0 (± 2.2)  
BclI CC 96.4 (± 2.8) -2.3 (± 0.5) 0.02* 92.0 (± 3.7) -2.3 (± 0.6) 0.01*
  CG 90.7 (± 3.9) -2.8 (± 0.7)   89.3 (± 5.2) -3.1 (± 0.8)  
  GG 106.8 (± 6.4) -3.4 (± 1.2)   111.0 (± 7.2) -4.3 (± 1.3)  
FVC
TthIII CC 97.6 (± 2.6) -2.3 (± 0.4) 0.8 92.1 (± 3.7) -1.8 (± 0.6) 0.9
  CT 93.8 (± 3.5) -1.7 (± 0.6)   95.2 (± 5.0) -2.2 (± 0.8)  
  TT 92.3 (± 5.9) -1.6 (± 0.9)   92.8 (± 7.8) -1.8 (± 1.3)  
ER22/23EK GG 95.6 (± 9.7) -2.1 (± 1.4) 0.1 93.8 (± 19.4) -2.2 (± 2.7) 0.5
  AA + AG 86.4 (± 9.5) +1.0 (± 1.4)   89.4 (± 19.3) 0.6 (± 2.6)  
N363S AA 95.2 (± 6.3) -1.9 (± 1.2) 0.9 94.1 (± 8.9) -2.1 (± 2.0) 0.8
  GG + AG 94.9 (± 6.1) -2.2 (± 1.2)   88.4 (± 8.6) -1.7 (± 2.0)  
BclI CC 96.0 (± 2.5) -1.5 (± 0.4) 0.04* 91.7 (± 3.3) -1.3 (± 0.4) 0.02*
  CG 92.0 (± 3.5) -2.1 (± 0.6)   89.3 (± 4.7) -2.1 (± 0.8)  
  GG 104.0 (± 5.7) -2.8 (± 0.1)   107.8 (± 6.6) -3.6 (± 1.2)  
  1. Abbreviations: Y: years; FEV1: forced expiratory volume in 1 second; FVC: forced vital capacity. FEV1 and FVC are expressed as percentages of predicted values.
  2. Statistical analysis: Mixed model regression for FEV1, FVC according to age. Results are expressed as estimated value at 6 years (Y6 ± SD) and average decline per year (k ± SD). Mixed model equation is expressed as Yage = Y6 - k (age - 6). *p < 0.05.