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Table 2 Inhibition of IP-10 secretion in co-cultures. The effects of 100 nM p38 inhibitor BIRB-796, 100 nM beclomethasone, 500 nM IKK-2 inhibitor V, 100 nM PDE4 inhibitor rolipram, 1 μM PI3 kinase inhibitor and human 10 μg/ml CD40 antibody on secretion of IP-10 from co-cultures.

From: The role of IFN-γ in regulation of IFN-γ-inducible protein 10 (IP-10) expression in lung epithelial cell and peripheral blood mononuclear cell co-cultures

  Calu-3/PBMC A549/PBMC
  Basal IFN-γ IL-12 Basal IFN-γ IL-12
BIRB-796 84 (± 7) ** 18 (± 6) 85 (± 6) ** 94 (± 2) *** 14 (± 6) 21 (± 8)
IKK-2 inh. V 75 (± 11) * 3 (± 1) 60 (± 13) 90 (± 5) * 4 (± 6) 17 (± 5)
Beclomet. 97 (± 1) *** -7 (± 6) 94 (± 2) *** 89 (± 8) ** 1 (± 4) 43 (± 14) *
Rolipram 62 (± 13) * 8 (± 2) 82 (± 10) * 77 (± 11) ** 17 (± 15) 0.6 (± 4)
PI3 kin. Inh. 91 (± 5) *** 54 (± 9) 96 (± 3) ** 96 (± 3) *** 50 (± 7) 77 (± 8)
CD40 ab -14 (± 14) -2 (± 7) -5 (± 25) 19 (± 10) -9 (± 12) -12 (± 10)
  1. Data represents the percentage of inhibition, mean (SEM). ***p < 0.001, **p < 0.01, *p < 0.05, ANOVA with Bonferroni's multiple comparison test.