Table 2 Inhibition of IP-10 secretion in co-cultures. The effects of 100 nM p38 inhibitor BIRB-796, 100 nM beclomethasone, 500 nM IKK-2 inhibitor V, 100 nM PDE4 inhibitor rolipram, 1 μM PI3 kinase inhibitor and human 10 μg/ml CD40 antibody on secretion of IP-10 from co-cultures.
Calu-3/PBMC | A549/PBMC | |||||
|---|---|---|---|---|---|---|
Basal | IFN-γ | IL-12 | Basal | IFN-γ | IL-12 | |
BIRB-796 | 84 (± 7) ** | 18 (± 6) | 85 (± 6) ** | 94 (± 2) *** | 14 (± 6) | 21 (± 8) |
IKK-2 inh. V | 75 (± 11) * | 3 (± 1) | 60 (± 13) | 90 (± 5) * | 4 (± 6) | 17 (± 5) |
Beclomet. | 97 (± 1) *** | -7 (± 6) | 94 (± 2) *** | 89 (± 8) ** | 1 (± 4) | 43 (± 14) * |
Rolipram | 62 (± 13) * | 8 (± 2) | 82 (± 10) * | 77 (± 11) ** | 17 (± 15) | 0.6 (± 4) |
PI3 kin. Inh. | 91 (± 5) *** | 54 (± 9) | 96 (± 3) ** | 96 (± 3) *** | 50 (± 7) | 77 (± 8) |
CD40 ab | -14 (± 14) | -2 (± 7) | -5 (± 25) | 19 (± 10) | -9 (± 12) | -12 (± 10) |