Figure 1

A. Ratio of right ventricle to left ventricle + septum weight [RV/(LV+S)] on day 15 in control untreated mice, MCTp-treated mice, MCTp-treated mice injected with bone marrow-derived cells (BMDCs), and MCTp-treated mice injected with irradiated BMDCs. Values are means ± SEM for 6 animals in each group except control mice (n = 15). B. Right ventricular systolic pressure (RVSP) on day 15 in control untreated mice, MCTp-treated mice, MCTp-treated mice injected with BMDCs, and MCTp-treated mice injected with irradiated BMDCs. Values are means ± SEM for 5 animals in each group except control mice (n = 8). C. Percentage of muscularized intraacinar vessels in lungs on day 15 in control untreated mice, MCTp-treated mice, MCTp-treated mice injected with BMDCs, and MCTp-treated mice injected with irradiated BMDCs. The percentage of pulmonary vessels in each muscularization category was determined by dividing the number of vessels in that category by the total number counted in the same experimental group. Values are means ± SEM for 5 animals in each group except control mice (n = 11). D. Representative panels of proximal artery remodeling. D1) normal artery in a control mouse; D2) MCTp-treated mouse with smooth muscle cell proliferation; D3) MCTp-treated mouse injected with bone marrow-derived cells (BMDCs) showing recovery of a nearly normal arterial morphology; D4) MCTp-treated mice injected with irradiated BMDCs showing no amelioration of remodeling or SMC proliferation. Sections were stained with hematoxylin-phloxine-saffron. Original magnification ×500.